Study to Test How Well Patients With Advanced Solid Tumors Respond to Treatment With the Elimusertib in Combination With Pembrolizumab, to Find the Optimal Dose for Patients, How the Drug is Tolerated and the Way the Body Absorbs, Distributes and Discharges the Drug

Inclusion Criteria:

   - Participant must be ≥18 years of age inclusive, at the time of signing the informed
   consent.

   - Presence of the putative biomarkers of DDR deficiency in tumor and/or other tissues
   (dose escalation only).

   - Participants must have histologically confirmed solid tumors .

   - Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0 to 1.

   - Adequate bone marrow function as assessed by laboratory tests to be conducted within 7
   days before the first dose of study intervention.

   - Participants must have adequate kidney function, as assessed by the estimated
   glomerular filtration rate (eGFR) > 40 mL/min per 1.73 m*2 within 7 days before the
   first dose of study intervention.

   - Participants must have adequate liver function as assessed by laboratory tests to be
   conducted within 7 days before the first dose of study intervention.

   - Participants must have adequate coagulation, as assessed by laboratory tests as
   applicable, (to be conducted within 7 days before the first dose of study
   intervention) or be on stable anti-coagulation treatment.

   - Adequate cardiac function per institutional normal measured by echocardiography
   (recommended) or multigated acquisition (MUGA) scan/cardiac MRI per institutional
   guidelines.

   - Participants must have measurable disease (at least one measurable lesion) as per
   RECIST 1.1, or evaluable disease according to the Prostate Cancer Clinical Trials
   Working Group 3 (PCWG3) classification as applicable. Lesions situated in a previously
   irradiated area are considered measurable if progression has been demonstrated in such
   lesions

Exclusion Criteria:

   - Ongoing infections of Common terminology criteria for adverse events (CTCAE) grade ≥2
   not responding to therapy or active clinically serious infections.

   - Participants with

      - Known human immunodeficiency virus (HIV)

      - Active Hepatitis B infection (positive for Hepatitis B surface antigen (HBsAg)/
      Hepatitis B virus (HBV) DNA).

      - Active Hepatitis C infection (positive anti-HCV Antibody and quantitative HCV RNA
      results greater than the lower limits of detection of the assay).

   - Active autoimmune disease (active defined as having autoimmune disease related
   symptoms and detectable autoantibodies) that has required systemic treatment in the
   past 2 years (i.e., with use of disease-modifying agents, corticosteroids, or
   immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic
   corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is
   not considered a form of systemic treatment

   - Diagnosis of immunodeficiency or participant is receiving chronic systemic steroid
   therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form
   of immunosuppressive therapy within 7 days prior to the first dose of study
   intervention. The use of physiologic doses of corticosteroids may be approved after
   consultation with the sponsor.

   - Pleural effusion or ascites that causes respiratory compromise (CTCAE Grade ≥ 2
   dyspnea).

   - History of cardiac disease: congestive heart failure New York Heart Association (NYHA)
   class >II, unstable angina (angina symptoms at rest), new-onset angina (within the
   past 6 months before study entry), myocardial infarction within the past 6 months
   before study entry, or cardiac arrhythmias requiring anti-arrhythmic therapy (beta
   blockers, calcium channel blockers, and digoxin are permitted)

   - Uncontrolled arterial hypertension despite optimal medical management (per
   investigator's opinion)

   - Moderate or severe hepatic impairment, i.e., Child-Pugh class B or C.

   - History of organ allograft transplantation

   - Evidence or history of bleeding disorder, i.e., any hemorrhage / bleeding event of
   CTCAE Grade > 2 within 4 weeks before the first dose of study intervention