Trial Search Results

Predicting Endometrial Receptivity for Optimal Reproductive Management

The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for endometriosis and predicting implantation and pregnancy rate after embryo transfer.

This study design will provide for the first time, an opportunity to compare endometrial biopsy material from hyperstimulated (gonadotropin treated) subjects after egg retrieval. If successful, it would provide a new protocol for women with unexplained infertility or those with known endometriosis to avoid poor IVF outcomes.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Stanford Investigator(s):

Intervention(s):

  • Procedure: Endometrial Biopsy
  • Other: Euploid embryo transfer
  • Diagnostic Test: Blood sample

Eligibility


Inclusion Criteria:

   1. Age - 18 to 42

   2. AMH ≥ 1

   3. Planning to undergo IVF with delayed embryo transfer

   4. Must have blastocyst(s) by day 6 that were biopsied for PGT-A

   5. BMI 18-35

Exclusion Criteria:

   1. Uterine fibroids > 4 cm in size

   2. Polycystic ovary syndrome (PCOS) according with the Rotterdam criteria.

   3. Ovarian failure and subjects receiving donor oocytes/embryos

   4. Anti-cardiolipid and/or lupus anti-coagulant abnormalities by history

   5. Diabetes mellitus (Type I or Type II)

   6. Untreated hypothyroidism

   7. Hyperprolactinemia

   8. Uncorrected uterine anomaly

Ages Eligible for Study

18 Years - 42 Years

Genders Eligible for Study

Female

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Raquel Fleischmann, DVM
408-426-5586
Recruiting