Intermittent Theta-Burst Stimulation to Target Irritability in Adults With ASD

Inclusion Criteria:

   1. Diagnosis of ASD or Asperger's based on DSM-5 criteria as confirmed by a qualified
   clinician (including Dr. Fung), and if necessary the administration of Autism
   Diagnostic Interview-Revised (ADI-R) and/or Autism Diagnostic Observation
   Schedule-Generic (ADOS-G)

   2. Age 22 to 55.

   3. Adults who are physically healthy.

   4. No significant current psychosocial stressors per history.

   5. Full scale IQ > 50.

   6. ABC-I score of 18 or greater.

   7. if the participant is taking medication, they must be stable on this medication
   regiment for at least 4 weeks prior to baseline and agree to stay on these medications
   for the duration of the trial

Exclusion Criteria:

(f) Pre-term birth (<34 weeks' gestation) (g) Low birth weight (<2000 g). (h) DSM-5
diagnosis of other severe psychiatric disorder such as bipolar disorder or schizophrenia.

(i) Current use of benzodiazepines. (j) Use of other medications that modulate the GABA(A)
receptor within 4 weeks of scanning (8 weeks for fluoxetine).

(k) History of alcoholism or substance abuse. (l) Active medical problems such as unstable
seizures, congenital heart disease, endocrine disorders.

(m) Significant sensory impairments such as blindness or deafness. (n) Contraindication for
MRI. (o) Pregnancy. (p) evidence of genetic syndrome.