IO-202 as Monotherapy and IO-202 Plus Azacitidine ± Venetoclax in Patients in AML and CMML

Inclusion Criteria:

   1. Patients must be ≥18.

   2. For the Part 1 Dose-Escalation Phase, patients must be diagnosed with the following:

      1. Relapsed or refractory AML with myelomonocytic or monoblastic/monocytic
      differentiation according to the World Health Organization 2016 criteria and has
      failed treatment with available therapies known to be active for AML.

      2. Relapsed or refractory CMML and has failed treatment with available therapies
      known to be active for CMML

   3. Part 2 Expansion Phase:

      1. Relapsed or refractory LILRB4high AML with myelomonocytic or
      monoblastic/monocytic differentiation and has failed treatment with available
      therapies known to be active for AML.

      2. Hypomethylating-agent naive CMML regardless of LILRB4 expression levels.

      3. Newly diagnosed high LILRB4 expression monocytic AML patients considered to be
      ineligible for standard induction therapy.

   4. Patients must be amenable to serial BM aspirates/biopsies and peripheral blood
   sampling during the study.

   5. Patients must be able to understand and willing to sign an informed consent. A legally
   authorized representative may consent.

   6. Patients must have an ECOG performance status of 0 to 2

   7. Patients must have adequate hepatic function

   8. Patients must have adequate renal function

   9. Patients must be recovered from any clinically relevant toxic effects of any prior
   surgery, radiotherapy, or other therapy intended for the treatment of cancer.

10. Patients must be off systemic calcineurin inhibitors for at least 4 weeks prior to
   study drug treatment.

11. Female patients with reproductive potential must have a negative serum pregnancy test
   within 7 days prior to the start of therapy.

Exclusion Criteria:

   1. Patients who have previously received a monoclonal antibody therapy targeting LILRB4.

   2. Patients who have undergone HSCT within 60 days of the first dose of IO-202.

   3. Patients who received systemic anti-cancer therapy or radiotherapy <7 days prior to
   their first day of study drug administration (Hydroxyurea or leukapheresis is allowed
   up to 24 hours prior to the first dose.

   4. Patients who received an investigational agent <7 days prior to their first day of
   study drug administration.

   5. Patients for whom potentially curative anti-cancer therapy is available.

   6. Patients who are pregnant or breastfeeding.

   7. Patients with uncontrolled, active infection.

   8. Patients with known hypersensitivity to any of the components of the IO-202
   formulation.

   9. Patients with known pulmonary lesions and/or history of pneumonitis or interstitial
   lung disease.

10. Active known malignancy.

11. Patients with New York Heart Association (NYHA) Class III or IV congestive heart
   failure (CHF) or left ventricular ejection fraction (LVEF) <40%.

12. Ongoing cardiac dysrhythmias Grade 2 or higher per of NCI CTCAE, Version 5.0, Grade
   ≥2.

13. Known or suspected hypersensitivity to recombinant proteins.

14. Known active bacterial, viral, and/or fungal infection.

15. Patients with any psychological, familial, sociological, or geographical condition
   potentially hampering compliance with the study protocol.

16. Patients with clinical signs and/or symptoms suggesting active, uncontrolled central
   nervous system (CNS) leukemia or known active, uncontrolled CNS leukemia.

17. Patients with immediately life-threatening, severe complications of leukemia.

18. Donor Lymphocyte Infusion within 30 days prior to first IO-202 administration.

19. Current active treatment in another interventional therapeutic clinical study.

20. Chronic systemic corticosteroid treatment with a dose of >10 mg prednisone/day or dose
   equivalent.

21. Other severe acute or chronic medical or psychiatric condition or laboratory
   abnormality that may increase the risk associated with study participation or
   investigational product administration or may interfere with the interpretation of
   study results and, in the judgment of the Investigator, would make the patient
   inappropriate for entry into this study.

22. Acute Promyelocytic Leukemia patients or patients with known Philadelphia chromosome
   (Ph+) positive AML or chronic myelogenous leukemia (CML) blast crisis.

23. Hyperleukocytosis (leukocytes ≥25 x 10e9/L) at first dose of IO-202.