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Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction
Not Recruiting
Trial ID: NCT04406584
Purpose
This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PrP) in the
treatment of olfactory dysfunction. PrP can be isolated from a patient's own blood and has
been found in previous studies to have anti-inflammatory and pro-regenerative properties. It
has been used across multiple specialties, such as Orthopedics, Facial Plastics, Dermatology,
Neurology in injected form to treat a wide variety of tissues to encourage the body's
inherent regenerative capacity. The investigators have completed a pilot study here
evaluating it's use in olfactory loss which demonstrated safety and also suggested efficacy.
Therefore, the investigators aim to assess the ability of PrP to improve olfactory function
in patients with decreased sense of smell.
Official Title
Intranasal Injection of Platelet-rich Plasma Versus Saline for Treatment of Olfactory Dysfunction
Stanford Investigator(s)
Zara Patel, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Eligibility
Inclusion Criteria:
- Patients >= 18 years of age
- Patients who have olfactory loss (based off of UPSIT score <= 33 out of 40)
- Patients who also have an age-adjusted TDI Sniffin' Sticks score that demonstrates
hyposmia (TDI>16 and <30)
- Etiology of olfactory loss is due to URI or idiopathic
- At least 6 months of olfactory loss but less than 12 months
- Patients can have been previously treated with oral and topical steroids but this is
not a requirement
- Patients will receive concurrent olfactory training - the practice of smelling strong
odors (standard of care)
- Be able to read and understand English
- Agree to participate in the study
- Be able and willing to provide Informed Consent
Exclusion Criteria:
- Patients < 18 years of age
- Pregnant females
- Patient who have any structural abnormalities on nasal endoscopy or radiographic
imaging
- Olfactory loss due to trauma, chronic sinusitis / inflammation / polyps, neoplasms, or
neurodegenerative diseases
- Patients who have had olfactory loss > 12 months
- Patients with bleeding disorders or on blood thinners such as coumadin and plavix
Intervention(s):
procedure: Injection into olfactory cleft
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Zara M Patel, MD
650-723-5651