Trial Search Results
Daratumumab-SC for Highly Sensitized Patients Awaiting Heart Transplantation
The purpose of this study is to test whether Daratumumab-SC, a drug that eliminates antibody-producing plasma cells, can effectively lower the level of preformed antibodies in patients awaiting heart transplantation. These preformed antibodies limit the number of donor hearts that are compatible for the patients. If Daratumumab-SC can effectively remove preformed, donor-specific antibodies, then highly allosensitized patients will have more compatible hearts available to them, potentially decreasing transplant waitlist time and reducing mortality.
Stanford is currently not accepting patients for this trial.
- Drug: Daratumumab-SC
- Participant is on an active list for a heart transplant.
- Participant has a high level of allosensitization, defined as a calculated PRA (panel
of reactive antibodies) of 50%, based on their antibody status at the time of entry
into the study.
- Ability to understand and willingness to sign an informed consent form prior to any
- Women of childbearing potential must have a negative pregnancy test at screening.
- Both male and female patients must use effective methods of birth control, must not
donate eggs or sperm during the course of the study and for 3 months after stopping
- Adequate bone marrow function.
- Adequate renal function (estimated GFR greater than or equal to 15 mL/min by the
- History of allergy or intolerance to daratumumab or Daratumumab-SC.
- Prior diagnosis of myeloma or light chain amyloidosis.
- Active infection.
- Women who are pregnant or breastfeeding.
- Ongoing desensitization treatment with another agent. Subjects are excluded if they
- a. IVIG within 30 days of enrollment.
- b. Proteasome inhibitor within 60 days of enrollment.
- c. Rituximab within 180 days of enrollment.
- Any condition which could interfere with, or the treatment for which might interfere
with, the conduct of the study or which would, in the opinion of the Investigator,
unacceptably increase the subject's risk by participating in the study.
- Contraindication to herpes zoster prophylaxis.
- Known to be seropositive for human immunodeficiency virus (HIV).
- Known to be seropositive for hepatitis B (defined by a positive test for hepatitis B
surface antigen [HBsAg]). Subjects with resolved infection (ie, subjects who are HBsAg
negative but positive for antibodies to hepatitis B core antigen [anti-HBc] and/or
antibodies to hepatitis B surface antigen [anti-HBs]) must be screened using real-time
polymerase chain reaction (PCR) measurement of hepatitis B virus (HBV) DNA levels.
Those who are PCR positive will be excluded. EXCEPTION: Subjects with serologic
findings suggestive of HBV vaccination (anti-HBs positivity as the only serologic
marker) AND a known history of prior HBV vaccination, do not need to be tested for HBV
DNA by PCR.
- Known to be seropositive for hepatitis C (except in the setting of a sustained
virologic response (SVR), defined as aviremia at least 12 weeks after completion of
- Known chronic obstructive pulmonary disease (COPD) with a forced expiratory volume in
1 second (FEV1) <50% of predicted normal. Note that FEV1 testing is required for
subjects suspected of having COPD and subjects must be excluded if FEV1 is <50% of
- Known moderate or severe persistent asthma within the past 2 years, or uncontrolled
asthma of any classification.
- Known history of human immunodeficiency virus (HIV).
- History of blood product transfusion within 60 days of enrollment, or anticipated need
for blood product transfusion during the course of the study.
- Moderate-severe liver dysfunction.
Ages Eligible for Study
18 Years - 75 Years
Genders Eligible for Study