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MRI QSM Imaging for Iron Overload
Not Recruiting
Trial ID: NCT04631718
Purpose
The overall goal of this project is to develop and validate a novel technique for Magnetic
Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM) of the abdomen, for
non-invasive assessment of liver iron deposition. In this work, study team will develop and
optimize advanced data acquisition and image reconstruction methods to enable QSM of the
abdomen. Further, investigators will determine the accuracy, repeatability, and
reproducibility of abdominal QSM for iron quantification in patients with liver iron
overload.
Excessive accumulation of iron in various organs, including the liver, which affects both
adult and pediatric populations, is toxic and requires treatment aimed at reducing body iron
stores. Accurate assessment of liver iron concentration is critical for the detection and
staging of iron overload as well as for longitudinal monitoring during treatment.
In summary, this project will develop a novel MRI-based QSM technique designed for the
abdomen and will validate it in pediatric and adult patients with liver iron overload. Upon
successful validation, QSM will provide accurate, repeatable, and reproducible quantification
of LIC based on a fundamental property of tissue.
Official Title
MRI-based Quantitative Susceptibility Mapping of Hepatic Iron Overload
Stanford Investigator(s)
Shreyas Vasanawala, MD/PhD
William R. Brody Professor of Pediatric Radiology and Child Health
Eligibility
Inclusion Criteria:
- Ages 10 years or older at University of Wisconsin - Madison
- Age 5 years or older at Stanford
- Known or suspected iron overload
Exclusion Criteria:
- Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic
implants, etc)
- Pregnant or trying to become pregnant (as determined by self-report during MRI safety
screening)
- Patients requiring intravenous (IV) conscious sedation for imaging are not eligible;
patients requiring mild, oral anxiolytics for the MRI will be allowed to participate
as long as the following criteria are met:
- The subject has their own prescription for the medication.
- The informed consent process is conducted prior to the self-administration of
this medication
- They come to the research visit with a driver
Intervention(s):
radiation: Magnetic Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM)
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Shreyas Vasanawala, MD, PhD
650-723-8087