Trial Search Results

MRI QSM Imaging for Iron Overload

The overall goal of this project is to develop and validate a novel technique for Magnetic Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM) of the abdomen, for non-invasive assessment of liver iron deposition. In this work, study team will develop and optimize advanced data acquisition and image reconstruction methods to enable QSM of the abdomen. Further, investigators will determine the accuracy, repeatability, and reproducibility of abdominal QSM for iron quantification in patients with liver iron overload.

Excessive accumulation of iron in various organs, including the liver, which affects both adult and pediatric populations, is toxic and requires treatment aimed at reducing body iron stores. Accurate assessment of liver iron concentration is critical for the detection and staging of iron overload as well as for longitudinal monitoring during treatment.

In summary, this project will develop a novel MRI-based QSM technique designed for the abdomen and will validate it in pediatric and adult patients with liver iron overload. Upon successful validation, QSM will provide accurate, repeatable, and reproducible quantification of LIC based on a fundamental property of tissue.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

University of Wisconsin, Madison

Collaborator: Stanford University

Stanford Investigator(s):

Intervention(s):

  • Radiation: Magnetic Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM)

Eligibility


Inclusion Criteria:

   - Ages 10 years or older

   - Known or suspected iron overload.

   - Past serum ferritin > 500

Exclusion Criteria:

   - Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic
   implants, claustrophobia, etc)

   - Pregnant or trying to become pregnant (as determined by self-report during MRI safety
   screening)

Ages Eligible for Study

10 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Shreyas Vasanawala, MD, PhD
650-723-8087
Not Recruiting