Trial Search Results

Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery

The purpose of the research is to assess the effectiveness of a dose of intravenous tranexamic acid (TXA) given intraoperatively to reduce postoperative bleeding after endoscopic sinus or nasal surgery (e.g. septoplasty, endoscopic sinus surgery, turbinate surgery). This medication has been shown to decrease blood loss during this type of surgery, but the implications for bleeding following surgery are unclear. Any impact on postoperative bleeding will be assessed over the first 7 days following surgery leading up to the first scheduled postoperative clinic visit. Patients will keep a standardized daily diary of their bleeding experience by indicating on a 0-10 visual analog scale (VAS) their impression of their bleeding.

The primary outcome is the patient-reported visual analog scale (VAS) bleeding score on each day after surgery. The secondary outcomes include the the frequency with which the otolaryngology resident service is requested to evaluate patients in the recovery unit for postoperative bleeding concerns and the frequency of interventions such as application of hemostatic materials, packing, cautery, and/or return to the operating room.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Drug: Tranexamic Acid 1,000 Mg/10 mL (100 Mg/mL) INTRAVEN VIAL (ML)

Phase:

Phase 4

Eligibility


Inclusion Criteria:

   - Scheduled to undergo elective sinus or nasal surgery (e.g. septoplasty, inferior
   turbinate reduction, endoscopic sinus surgery)

   - Age 18 or greater

   - English-speaking

   - Able to provide consent

Exclusion Criteria:

   - Minors (age<18)

   - Pregnant or may become pregnant by time of surgery

   - Prisoners

   - Non-English speaking

   - Foreign citizens

   - Unable to provide consent

   - Known pro-thrombotic coagulation disorders

   - Active intranasal drug use (e.g. cocaine)

   - Surgery is for a sinonasal tumor or other sinus pathology not described in inclusion
   criteria

   - Enrollment is in conflict with existing study participation

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305