Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)

Inclusion Criteria:

INFECTED COHORT -- ADULTS WITH SUSPECTED SARS-COV-2 INFECTION --

An adult qualifies as having suspected SARS-CoV-2 infection if meeting criteria a, b or c
below:

   1. Patients who meet the following clinical criteria plus one of the epidemiological
   criteria:

   Clinical Criteria: Acute onset of fever and cough OR acute onset of any three of more
   of the following signs or symptoms: fever, cough, general weakness /fatigue, headache,
   myalgia, sore throat, coryza, dyspnea, anorexia/nausea/vomiting, diarrhea, altered
   mental status.

   Epidemiological Criteria:

      1. Residing or working in an area with a high risk of transmission of virus: closed
      residential settings, humanitarian settings such as camp and camp-like settings
      for displaced persons; anytime within the 14 days before symptom onset; or

      2. Residing or travel to an area with community transmission anytime within the 14
      days before symptom onset; or

      3. Working in any health care setting, including within health facilities or within
      the community; anytime within the 14 days before symptom onset.

   2. A patient with severe acute respiratory illness: (acute respiratory infection with
   history of fever or measured fever of ≥38C°; and cough; with onset within the last 10
   days; and requires hospitalization).

   3. An asymptomatic person not meeting epidemiologic criteria with a positive SARS-CoV-2
   Antigen-RDT.

ADULTS WITH PROBABLE SARS-COV-2 INFECTION --

An adult qualifies as having probable SARS-CoV-2 infection if meeting any one of a-d below:

   1. A patient who meets clinical criteria for suspected SARS-CoV-2 AND is a contact of a
   probable or confirmed case or linked to a COVID-19 cluster;

   2. A suspect case with chest imaging showing findings suggestive of COVID-19 disease;

   3. A person with recent onset of anosmia (loss of smell) or ageusia (loss of taste) in
   the absence of any other identified cause;

   4. Death, not otherwise explained, in an adult with respiratory distress preceding death
   AND was a contact of a probable or confirmed case or linked to a COVID-19 cluster

ADULTS WITH CONFIRMED SARS-COV-2 INFECTION --

An adult qualifies as having confirmed SARS-CoV-2 infection if meeting any one of a-d
below:

   1. Any person with a positive Nucleic Acid Amplification Test (NAAT);

   2. Any person with a positive SARS-CoV-2 Antigen-RDT OR positive SARS-CoV-2 antibody
   test* AND meeting either the probable case definition or suspect criteria A OR B;

   3. An asymptomatic person with a positive SARS-CoV-2 Antigen-RDT who is a contact of a
   probable or confirmed case

   4. Any person with a positive SARS-CoV-2 nucleocapsid protein antibody test OR a positive
   SARS-CoV-2 spike protein antibody test IF not vaccinated

      - (*)This protocol modifies the WHO criterion b to add detectable SARS-CoV-2
      antibody as a qualifying test.

UNINFECTED COHORT -- ADULTS WITH NO SARS-COV-2 INFECTION --

   - Does not meet WHO criteria for a suspected, probable, or confirmed case of SARS-CoV-2
   infection, AND

   - Has a documented negative SARS-CoV-2 PCR test from a respiratory specimen in the past,
   if being enrolled as a post-acute control (see XII.H), AND

   - Has a documented negative SARS-CoV-2 PCR test from a respiratory specimen at the time
   of enrollment/screening, AND

   - Has a negative SARS-CoV-2 nucleocapsid protein antibody and spike protein antibody
   test (spike only if not vaccinated) at the time of enrollment, AND

   - Live in the same communities or recruited from the same sources as those in the
   SARS-CoV-2 infected cohort, AND

   - Note: uninfected individuals may participate independent of their vaccination status

Exclusion Criteria:

   - Individuals who have not yet reached the age of majority

   - Unable to provide consent

   - Individuals in hospice care

   - Any serious medical condition which would prevent long-term participation

   - Individuals participating in the study NIH RECOVER-Pediatric: Understanding the
   long-term impact of COVID on children and families

   - Incarcerated individuals