Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System

Inclusion Criteria:

   - Able to comprehend and willing to sign an informed consent form (ICF).

   - Diagnosis of local, loco-regionally advanced, or metastatic malignancy for whom
   radiotherapy is indicated

   - Radiotherapy to be delivered on the RMRS X1 with IMRT or SBRT technique.

   - Absence of concurrent illness that deems radiotherapy a contraindication which will be
   determined by the treating radiation oncologist.

   - Female and male patients of child-bearing potential willing to take appropriate
   precautions to avoid pregnancy while being treated. Permitted methods in preventing
   pregnancy should be communicated to the patient and their understanding confirmed by
   the treating Physician.

Exclusion Criteria:

   - Pregnant or expecting to conceive during the study.

   - Has a known psychiatric or substance abuse disorder that would interfere with the
   participant's ability to cooperate with study requirements and follow-up visits.

   - Inability to maintain immobilization, supine position for planning and treatments.