Pediatric Trials

Study of Kidney Tumors in Younger Patients

This research trial studies kidney tumors in younger patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Children's Oncology Group

Collaborator: National Cancer Institute (NCI)

Stanford Investigator(s):

Intervention(s):

  • Other: Cytology Specimen Collection Procedure
  • Other: Laboratory Biomarker Analysis

Eligibility


Inclusion Criteria:

   - Patients with the first occurrence of any tumor of the kidney identified on CT scan or
   MRI are eligible for this study; histologic diagnosis is not required prior to
   enrollment but is required for all patients once on study

   - Eligible tumors include (but are not limited to):

      - Nephroblastic tumors

         - Nephroblastoma (Wilms' tumor) (favorable histology, anaplasia [diffuse,
         focal])

         - Nephrogenic rests and nephroblastomatosis

         - Cystic nephroma and cystic partially differentiated nephroblastoma

         - Metanephric tumors (metanephric adenoma, metanephric adenofibroma,
         metanephric stromal tumor)

      - Mesoblastic nephroma (cellular, classic, mixed)

      - Clear cell sarcoma

      - Rhabdoid tumor (any malignant rhabdoid tumor occurring outside the central
      nervous system [CNS])

      - Renal epithelioid tumors of childhood (papillary renal cell carcinoma, medullary
      renal cell carcinoma, renal tumors associated with Xp11.2 translocations,
      oncocytic renal neoplasms after neuroblastoma)

      - Angiolipoma

      - Ossifying renal tumor of infancy

   - Patients with the first occurrence of the following tumors are also eligible:

      - Extrarenal nephroblastoma or extrarenal neprogenic rests

      - Malignant rhabdoid tumor occurring anywhere outside the Central Nervous System

   - Required specimens, reports, and copies of imaging studies must be available for
   submission or must become available during the required timeframe

   - For ALL patients (with exception of bilateral, bilaterally predisposed or unilateral
   tumor in solitary kidney planning to enroll without biopsy), the following submissions
   are required:

      - A complete set of recut hematoxylin and eosin (H & E) slides**

      - Representative formalin-fixed paraffin-embedded tissue block or if a block is
      unavailable, 10 unstained slides from a representative block of tumor**

      - Institutional pathology report, transmittal form and pathology checklist

      - Copies of images and institutional reports of CT and/or MRI abdomen and pelvis

      - Copies of images and institutional report of CT chest for all malignant tumors

      - Institutional surgical report(s)

         - Tissue must be from diagnosis, prior to any chemotherapy or radiation

   - For patients with clinical features and required imaging findings consistent with the
   eligibility for the bilateral study, AREN0534 (or successor study), confirmed by
   central review, biopsy is not required; however, if biopsy is done, tissue must be
   submitted as for other renal tumors, and initial risk assignment will require
   pathology and surgical rapid central reviews; transmittal form and pathology checklist
   are also needed

   - Patients with extrarenal Wilms tumor must have tumor tissue available for central
   review

   - Patients with extra-CNS malignant rhabdoid tumor must have tumor tissue available for
   central review

   - All patients and/or their parents or legal guardians must sign a written informed
   consent

   - All institutional, Food and Drug Administration (FDA), and National Cancer Institute
   (NCI) requirements for human studies must be met

Ages Eligible for Study

N/A - 29 Years

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Christina Baggott
650-497-7659
Recruiting