Teaching Math Skills to Individuals With Fragile X Syndrome
Children with FXS are predisposed to manifesting a particular profile of intellectual strengths and weaknesses, including specific deficits in math, visual-spatial skills, executive functioning, and social skills. Until now, intensive behavioral interventions have not been targeted to syndrome-specific weaknesses. In the present study we will develop and evaluate behavioral strategies to aid skill acquisition in children with FXS.
Stanford is currently accepting patients for this trial.
- Behavioral: discrete-trial training
- (a) 10 to 23 years of age (this age range was chosen to maximize the probability that
subjects will cooperate with the imaging procedures as well as benefit from the
- (b) in good physical health,
- (c) able to participate in the imaging component of the project,
- (d) IQ between 50 and 80. We have found that individuals with IQ's less than 50 points
are generally unable to comply with the scanning procedures.
- (e) diagnosis of FXS (for FXS group) and non-specific developmental disorder (for
Exclusion criteria include
- contraindications for MRI (e.g., pacemaker, braces),
- the presence of neurological or sensory problems not associated with the conditions of
interest (e.g., head trauma, blindness), or inability to discontinue psychotropic
medication for 4 weeks prior to the scan.
- Additional exclusion criteria for the control group include the presence of any known
identifiable syndrome (e.g., fragile X syndrome, Down syndrome, Prader-Willi syndrome,
Turner syndrome, PKU, fetal alcohol syndrome, Williams syndrome).
Ages Eligible for Study
10 Years - 23 Years
Genders Eligible for Study