Pediatric Trials

Teaching Math Skills to Individuals With Fragile X Syndrome

Children with FXS are predisposed to manifesting a particular profile of intellectual strengths and weaknesses, including specific deficits in math, visual-spatial skills, executive functioning, and social skills. Until now, intensive behavioral interventions have not been targeted to syndrome-specific weaknesses. In the present study we will develop and evaluate behavioral strategies to aid skill acquisition in children with FXS.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University


  • Behavioral: discrete-trial training




Inclusion Criteria:

   - (a) 10 to 23 years of age (this age range was chosen to maximize the probability that
   subjects will cooperate with the imaging procedures as well as benefit from the

   - (b) in good physical health,

   - (c) able to participate in the imaging component of the project,

   - (d) IQ between 50 and 80. We have found that individuals with IQ's less than 50 points
   are generally unable to comply with the scanning procedures.

   - (e) diagnosis of FXS (for FXS group) and non-specific developmental disorder (for
   control group).

Exclusion Criteria:

Exclusion criteria include

   - contraindications for MRI (e.g., pacemaker, braces),

   - the presence of neurological or sensory problems not associated with the conditions of
   interest (e.g., head trauma, blindness), or inability to discontinue psychotropic
   medication for 4 weeks prior to the scan.

   - Additional exclusion criteria for the control group include the presence of any known
   identifiable syndrome (e.g., fragile X syndrome, Down syndrome, Prader-Willi syndrome,
   Turner syndrome, PKU, fetal alcohol syndrome, Williams syndrome).

Ages Eligible for Study

10 Years - 23 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Scott Hall, PhD