Christopher Lock

Clinical Associate Professor, Neurology & Neurological Sciences

Clinical Focus

Multiple Sclerosis
Neuroimmunology
Neurology

Academic Appointments

Clinical Associate Professor, Neurology & Neurological Sciences

Administrative Appointments

Clinical Trials Director, Stanford Multiple Sclerosis and Neuroimmunology Program (2015 - Present)
Member, SHC Pharmacy and Therapeutics Specialty Drug Sub-Committee (2016 - 2017)

Boards, Advisory Committees, Professional Organizations

Member, American Academy of Neurology (1994 - Present)

Professional Education

Board Certification: American Board of Psychiatry and Neurology, Neurology (2020)
Fellowship: Stanford University Neuroimmunology and Multiple Sclerosis Fellowship (2000) CA
Residency: Stanford University Neurology Residency (1997) CA
Internship: Stanford University Internal Medicine Residency (1994) CA
Medical Education: Westminster Medical School (1980) England

Contact

Academic lock@stanford.edu

Clinical Stanford Neuroscience Health Center 213 Quarry Rd MC 5957 Fl 2 Palo Alto CA 94304 Tel: (650) 723-6469 Fax: (650) 498-6045

All Publications

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Paul Bollyky

Associate Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Clinical Focus
Infectious Disease, Wound infections, Microbial biofilms, Diabetic wounds, Chronic skin and lung infections, Chronic bacterial infections
Research Interests
Chronic bacterial infections are a major health care problem. Our lab is interested in understanding the host and microbial factors that perpetuate chronic infections and in developing novel therapeutic interventions to improve human health.

111 Total Publications
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Marion S. Buckwalter, MD, PhD

Professor of Neurology and of Neurosurgery
Clinical Focus
Neurology, Neurologic Critical Care
Research Interests
The goal of the Buckwalter Lab is to improve how people recover after a stroke. We use basic and clinical research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. Ongoing projects are focused on understanding how inflammatory responses are regulated after a stroke and how they affect short-term brain injury and long term outcomes like dementia and depression.

95 Total Publications
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Yueh-hsiu Chien

Professor of Microbiology & Immunology
Research Interests
Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.

106 Total Publications
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Edgar Engleman

Professor of Pathology and of Medicine (Immunology and Rheumatology)
Research Interests
Dendritic cells, macrophages, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer, autoimmune disease, neurodegenerative disease and metabolic disease.

286 Total Publications
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C. Garrison Fathman

Professor of Medicine (Immunology and Rheumatology), Emeritus
Research Interests
My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We have identified and characterized a gene (GRAIL) that seems to control regulatory T cell (Treg) responsiveness by inhibiting the Treg IL-2 receptor desensitization. We have characterized a gene (Deaf1) that plays a major role in peripheral tolerance in T1D. Using PBC gene expression, we have provisionally identified a signature of risk and progression in T1D.

326 Total Publications
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Jorg Goronzy

Professor of Medicine (Immunology and Rheumatology), Emeritus

479 Total Publications
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May Han, MD

Associate Professor of Neurology
Clinical Focus
Neurology, Neuroimmunology, Multiple sclerosis (MS), Neuromyelitis optica, High risk MS, MS pregnancy

75 Total Publications
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Yang Hu, MD, PhD

Associate Professor of Ophthalmology
Research Interests
The ultimate goal of the laboratory is to develop efficient therapeutic strategies to achieve CNS neural repair, through promoting neuroprotection, axon regeneration and functional recovery.

More specifically, we study retinal ganglion cell (RGC) and optic nerve in various optic neuropathies including traumatic, glaucomatous and inflammatory optic nerve injuries to fully understand the molecular mechanisms of CNS neurodegeneration and axon regeneration failure.

59 Total Publications
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Siddhartha Jaiswal

Assistant Professor of Pathology
Clinical Focus
Transfusion Medicine, Genomics and Molecular Pathology, Clinical Pathology
Research Interests
We identified a common disorder of aging called clonal hematopoiesis of indeterminate potential (CHIP). CHIP occurs due to certain somatic mutations in blood stem cells and represents a precursor state for blood cancer, but is also associated with increased risk of cardiovascular disease and death. We hope to understand more about the biology and clinical implications of CHIP using human and model system studies.

62 Total Publications
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Patricia Jones

The Dr. Nancy Chang Professor, Emerita
Research Interests
Dr. Jones' research has focused on genetic, molecular, and cellular mechanisms that regulate immune responses. Recent work was centered on the regulation of innate immune responses that are triggered by conserved microbial components. As these responses can be harmful they are highly regulated in their occurrence, magnitude, and duration. Her lab discovered a novel mechanism that negatively regulates innate responses, mediated by the phosphatase calcineurin.

31 Total Publications
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Tobias Lanz

Assistant Professor of Medicine (Immunology and Reumatology)

29 Total Publications
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David B. Lewis

Naddisy Foundation Professor of Pediatric Food Allergy, Immunology, and Asthma
Clinical Focus
Primary Immunodeficiency, Pediatrics
Research Interests
My laboratory is focused on defining cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. We are also determinomg how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants for influenza vaccine and by using catalytically inactive Cas proteins for inducing endogenous gene expression.

174 Total Publications