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Gynecologic malignancies; Rectal/and cancer; Breast Cancer; Hodgkin's disease; Hyperthermia; intraoperative radiation therapy; High dose rate radiation therapy; Predictive assays; Patterns of tumor spread; Health care finance.
Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer
This randomized phase III trial is studying cisplatin, radiation therapy, and tirapazamine to
see how well they work compared to cisplatin and radiation therapy in treating patients with
cervical cancer. Drugs used in chemotherapy, such as cisplatin and tirapazamine, work in
different ways to stop the growth of tumor cells, either by killing the cells or by stopping
them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Internal
radiation uses radioactive material placed directly into or near a tumor to kill tumor cells.
Cisplatin and tirapazamine may make tumor cells more sensitive to radiation therapy. It is
not yet known whether giving cisplatin together with radiation therapy is more effective with
or without tirapazamine in treating cervical cancer.
Stanford is currently not accepting patients for this trial.
For more information, please contact Maureen Sutton, 6507259167.
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