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Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Cel
Recruiting
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This is a phase Ib study to establish safety of Axi-Cel-2 in patients with Large B Cell
Lymphoma (LBCL) who are at high risk of relapse.
Lead Sponsor
Stanford Investigators
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Molecular Evaluation of AML Patients After Stem Cell Transplant to Understand Relapse Events
Recruiting
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Prospective determination of the clinical utility of measurable residual disease (MRD)
testing for relapse and survival of patients with acute myeloid leukemia (AML) undergoing
allogeneic hematopoietic cell transplantation (alloHCT).
Stanford Investigators
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B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme
Recruiting
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This is an open label, non-randomized, single site Phase I study to test the manufacturing
feasibility and safety of locoregional (LR) administration of B7-H3CART into the central
nervous system of adult subjects with recurrent IDH wild-type GBM using a standard 3+3 dose
escalation design.
Stanford Investigators
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The clonoSEQ® Watch Registry
Recruiting
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This is a prospective, multicenter, observational study of adult patients with a diagnosis of
acute lymphoblastic leukemia (ALL), multiple myeloma (MM), chronic lymphocytic leukemia
(CLL), or non-Hodgkin lymphoma (NHL). This study will enroll up to 528 patients in up to 50
sites in the United States and collect data with regard to use of the clonoSEQ MRD assay in
the management of lymphoid malignancies.
Stanford Investigators
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Study of KITE-222 in Participants With Relapsed/Refractory Acute Myeloid Leukemia
Not Recruiting
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The goal of this clinical study is to learn more about the safety and dosing of the study
drug, KITE-222, in participants with relapsed/refractory (r/r) acute myeloid leukemia (AML).
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Safety of Myeloablative Conditioning, Orca-T, and Allogeneic, Donor-Derived CD19/CD22-CAR (Chimeric Antigen Receptor) T Cells in Adults With B-cell Acute Lymphoblastic Leukemia (ALL)
Recruiting
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To assess the safety of administering allogenic, donor-derived CD19/CD22-CAR T cells that
meet established release specifications in adults with B-cell ALL following a myeloablative
conditioning regimen and Orca-T to determine if this will augment graft versus leukemia
without increasing acute GVHD or graft failure.
Stanford Investigators
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JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation
Not Recruiting
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This is a Phase 1a/b study to evaluate the safety and tolerability of an antibody
conditioning regimen known as JSP191, in combination with low dose radiation and fludarabine,
in subjects with Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) undergoing
allogenic blood stem cell transplantation.
Stanford is currently not accepting patients for this trial.
For more information, please contact Lori Muffly, MD,MS, .
Stanford Investigators
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Autologous CD22 CAR T Cells in Adults w/ Recurrent or Refractory B Cell Malignancies
Recruiting
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The primary purpose of this study is to test whether CD22-CAR T cells can be successfully
made from immune cells collected from adults with relapsed/refractory B-cell malignancies
(leukemia and lymphoma).
Lead Sponsor
Stanford Investigators
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Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation
Not Recruiting
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The purpose of this study is to evaluate whether addition of a low dose of total body
irradiation (TBI) to a standard preparation for transplant [total lymphoid irradiation (TLI)
and anti-thymocyte globulin (ATG)] conditioning will help to augment donor chimerism without
reducing tolerability of this regimen or increasing the risk of graft-vs-host disease (GVHD)
Stanford is currently not accepting patients for this trial.
For more information, please contact Sivan Yani, 650-498-7061.
Lead Sponsor
Stanford Investigators
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MAGE A10ᶜ⁷⁹⁶T for Advanced NSCLC
Recruiting
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This first time in human study is intended for men and women at least 18 years of age who
have advanced lung cancer which has grown or returned after being treated. In particular, it
is a study for subjects who have a blood test positive for HLA-A*02:01 and/or HLA-A*02:06 and
a tumor test positive for MAGE A10 protein expression (protein or gene). This trial is a dose
escalation trial that will evaluate 3 doses of transduced cells administered after a
lymphodepleting chemotherapy regimen using a 3+3 dose escalation design .The study will take
the subject's T cells, which are a natural type of immune cell in the blood, and send them to
a laboratory to be modified. The changed T cells used in this study will be the subject's own
T cells that have been genetically changed with the aim of attacking and destroying cancer
cells.
When the MAGE A10ᶜ⁷⁹⁶T cells are available, subjects will receive lymphodepleting
chemotherapy with cyclophosphamide and fludarabine, followed by the T cell infusion. The
purpose of this study is to test the safety of genetically changed T cells and find out what
effects, if any, they have in subjects with lung cancer. The study will evaluate three
different cell dose levels in order to find out the target cell dose. Once the target cell
dose is determined, additional subjects will be enrolled to further test the safety and
effects at this cell dose.
Subjects will be seen frequently by the Study Physician right after receiving their T cells
back and up to first 6 months. After that, subjects will be seen every three months. Subjects
will be seen every 6 months by their Study Physician for the first 5 years after the T cell
infusion. If the T cells are found in the blood at five years, then the subjects will
continue to be seen once a year until the T cells are no longer found in the blood for a
maximum of 15 years. If the T cells are no longer found in the blood at 5 years, then the
subject will be contacted by the Study Physician for the next 10 years. Subjects who have a
confirmed response or clinical benefit ≥4 weeks after the first T-cell infusion and whose
tumor continues to express the appropriate antigen target may be eligible for a second
infusion. All subjects, completing or withdrawing from the Interventional Phase of the study,
will enter a 15-year long-term follow-up phase for observation of delayed adverse events. All
subjects will continue to be followed for overall survival during the long-term follow-up
phase.
Stanford Investigators
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A Trial of the FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/Internal Tandem Duplication (ITD) Acute Myeloid Leukemia (AML)
Not Recruiting
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The purpose of this study is to compare relapse-free survival between participants with
FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem
cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after
the time of engraftment for a two year period.
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies
Not Recruiting
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The primary objective of this protocol is to provide expanded access to tabelecleucel to
participants with Epstein-Barr virus-associated diseases and malignancies for whom there are
no other appropriate therapeutic options, and who are not eligible to enroll in clinical
studies designed to support the development and registration of tabelecleucel.
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)
Not Recruiting
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To evaluate the safety and efficacy of ibrutinib in combination with prednisone in subjects
with newly diagnosed moderate to severe cGVHD.
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Phase I Dose Escalation Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies
Recruiting
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This phase I trial studies the best dose and side effects of CD19/CD22 chimeric antigen
receptor (CAR) T cells when given together with chemotherapy, and to see how well they work
in treating children or young adults with CD19 positive B acute lymphoblastic leukemia that
has come back or does not respond to treatment. A CAR is a genetically-engineered receptor
made so that immune cells (T cells) can attack cancer cells by recognizing and responding to
the CD19/CD22 proteins. These proteins are commonly found on B acute lymphoblastic leukemia.
Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in
different ways to stop the growth of cancer cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. Giving CD19/CD22-CAR T cells and
chemotherapy may work better in treating children or young adults with B acute lymphoblastic
leukemia.
Stanford Investigators
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CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies
Recruiting
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This phase I trial studies the side effects of CD19/CD22 chimeric antigen receptor (CAR) T
cells when given together with chemotherapy and NKTR-255, and to see how well they work in
treating patients with CD19 positive B acute lymphoblastic leukemia that has come back or
does not respond to treatment. A CAR is a genetically-engineered receptor made so that immune
cells (T cells) can attack cancer cells by recognizing and responding to the CD19/CD22
proteins. These proteins are commonly found on diffuse large B-cell lymphoma and B acute
lymphoblastic leukemia. Drugs used in chemotherapy, such as cyclophosphamide and fludarabine
phosphate, work in different ways to stop the growth of cancer cells, either by killing the
cells, by stopping them from dividing, or by stopping them from spreading. NKTR-255 is an
investigational IL-15 receptor agonist designed to boost the immune system's natural ability
to fight cancer. Giving CD19/CD22-CAR T cells and chemotherapy in combination with NKTR-255
may work better in treating patients with diffuse large B-cell lymphoma or B acute
lymphoblastic leukemia.
Stanford Investigators
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Obinutuzumab in cGVHD After Allogeneic Peripheral Blood Stem Cell Transplantation
Not Recruiting
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This research study is studying a drug called obinutuzumab as a means of preventing chronic
Graft vs. Host Disease (cGVHD).
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Donor Regulatory T Cells in Treating Patients With Visceral Acute Graft-versus-Host Disease After Stem Cell Transplant
Not Recruiting
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This phase I trial studies the side effects and best dose of donor regulatory T cells in
treating patients with graft-versus-host disease affecting the liver or gastrointestinal
organs (visceral) within 100 days (acute) after undergoing a stem cell transplant.
Graft-versus-host disease occurs when donor immune cells infused in a stem cell transplant
attack the gut, skin, liver, or other organ systems of the patient. Regulatory T cells are a
type of immune cell that may be able to reduce the attack of the donor's immune cells on the
patient's normal cells and help treat graft-vs-host disease.
Stanford is currently not accepting patients for this trial.
For more information, please contact Joanne Otani, 650-721-2372.
Stanford Investigators
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Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
Not Recruiting
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This randomized phase III trial studies how well standard-dose combination chemotherapy works
compared to high-dose combination chemotherapy and stem cell transplant in treating patients
with germ cell tumors that have returned after a period of improvement or did not respond to
treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin,
carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either
by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by
stopping them from dividing or killing them. Giving colony-stimulating factors, such as
filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem cells move from the
bone marrow to the blood so they can be collected and stored. Chemotherapy is then given to
prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the
patient to replace the blood-forming cells that were destroyed by the chemotherapy. It is not
yet known whether high-dose combination chemotherapy and stem cell transplant are more
effective than standard-dose combination chemotherapy in treating patients with refractory or
relapsed germ cell tumors.
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Study of Quality of Life in Older vs. Younger Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes
Not Recruiting
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This is a multi-center, Phase II, cross-sectional study comparing quality of life (QOL) as
assessed by patient-reported outcomes (PROs) in older (≥65 years) adults vs younger (55-64
years) undergoing allogeneic hematopoietic cell transplantation (HCT) for myelodysplastic
syndromes (MDS).
Stanford is currently not accepting patients for this trial.
For more information, please contact Michelle Chin, MS, 650-721-4183.
Stanford Investigators
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Safety and Efficacy of KTE-C19 in Combination With Atezolizumab in Adults With Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Not Recruiting
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The primary objective of phase 1 is to evaluate the safety of KTE-C19 and atezolizumab
combination regimens.
The primary objective of phase 2 is to evaluate the efficacy of KTE-C19 and atezolizumab, as
measured by complete response rate in participants with refractory diffuse large B-cell
lymphoma (DLBCL).
Subjects who received an infusion of KTE-C19 will complete the remainder of the 15 year
follow-up assessments in a separate long-term follow-up study, KT-US-982-5968
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Stanford Letter or Traditional Advance Directive in Advance Care Planning in Patients Undergoing Bone Marrow Transplant
Not Recruiting
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The purpose of the proposed research study is to evaluate whether bone marrow transplant
patients prefer the Stanford letter advance care planning tool to the standard Advance
directive.
Completion of advance care planning prior to BMT is very important, but not often done. The
investigators believe that the Stanford Letter will be preferred by patients and will allow
them to feel more comfortable and share more of their wishes with family members and the
medical team.
Stanford is currently not accepting patients for this trial.
For more information, please contact VJ PERIYAKOIL, MD, 650-493-5000 Ext. 61925.
Lead Sponsor
Stanford Investigators
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Ibrutinib in Treating Patients With Refractory or Relapsed Lymphoma After Donor Stem Cell Transplant
Recruiting
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This phase II trial studies how well ibrutinib works in treating patients after a donor stem
cell transplant for lymphoma that is not responding to treatment or has come back. Ibrutinib
may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Stanford Investigators
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Study of Effectiveness of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Patients With Relapsed/Refractory Diffuse Large B Cell Lymphoma
Not Recruiting
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The goal of this clinical study is to assess whether axicabtagene ciloleucel therapy improves
the clinical outcome compared with standard of care second-line therapy in patients with
relapsed/refractory diffuse large B-cell lymphoma (DLBCL).
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)
Not Recruiting
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The study is designed as a three arm randomized Phase III, multicenter trial comparing two
calcineurin inhibitor (CNI)-free strategies for Graft-versus-Host Disease (GVHD) prophylaxis
to standard tacrolimus and methotrexate (Tac/Mtx) in patients with hematologic malignancies
undergoing myeloablative conditioning hematopoietic stem cell transplantation.
Stanford is currently not accepting patients for this trial.
For more information, please contact Lori Muffly, .
Stanford Investigators
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Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders
Not Recruiting
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Allogeneic stem cell transplantation (transplant of blood cells from another individual) is a
treatment option for patients with myelodysplasia or myeloproliferative Disorders. During the
course of this study, it will be evaluated whether a particular type of blood cell, called a
cytokine-induced killer (CIK) cell, may add benefit to allogeneic stem cell transplantation.
CIK cells are present in small quantities in the bloodstream but their numbers can be
expanded after a brief period of nurturing in a laboratory.
Stanford is currently not accepting patients for this trial.
For more information, please contact Physician Referrals, 650-723-0822.
Stanford Investigators
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A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1)
Not Recruiting
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The purpose of this study was to assess the efficacy of ruxolitinib in combination with
corticosteroids in subjects with Grades II to IV steroid-refractory acute graft-versus-host
disease (GVHD).
Stanford is currently not accepting patients for this trial.
For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061.
Stanford Investigators
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