Support teaching, research, and patient care.
Interested in the genetics of human performance and the multi-omic response to exercise and training for optimizing human health.
GEnder Dysphoria Treatment in Sweden
Gender dysphoria (DSM-5) or transsexualism (ICD10) is a condition in which a person's feeling
of gender identity is not congruent with the physical body. The hormonal treatment includes
inhibition of one's own sex hormone production followed by treatment with testosterone or
estrogen levels that are normal for the opposite sex. Seen as experimental model, this is a
process that provides an opportunity to study the sex hormone dependent influences that
explain differences in morbidity in men and women respectively. The differences that are
especially significant but not well known is 1) metabolic changes in the regulation of
glucose homeostasis and lipid metabolism 2) regulation of vascular function and structural
effects on the heart and arteries 3) regulation of skeletal muscle mass and fat tissue 4)
morphological and functional effects on discrete areas of the brain.
Therefore, the investigators will follow these patients for a year to study how the heart,
blood vessels, brain, and risk factors for cardiovascular disease affected by altered sex
hormone patterns and studying what happens in the muscles and fat in both the short and long
term with respect to particular gene expression and epigenetic changes and link it to
metabolic changes and body composition.
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HIIT vs. MICT Training Study
The purpose of this study is to compare the impact of high-intensity interval training (HIIT)
versus moderate-intensity continuous training (MICT) on human health outcomes in healthy
sedentary subjects, over 12 weeks of exercise training.
The investigators will compare several health parameters, such as changes in multiomics
profile, cardiorespiratory fitness, muscle strength, and body composition, before and after
12-week interventions of either HIIT or MICT.
Molecular Transducers of Physical Activity Consortium
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess
molecular changes that occur in response to physical activity (PA). To achieve this aim, a
mechanistic randomized controlled trial (RCT) is conducted, in which adult study participants
are randomized to endurance exercise (EE) training, resistance exercise (RE) training, or no
exercise Control for a period of approximately 12 weeks. The overarching hypothesis is that
there are discoverable molecular transducers that communicate and coordinate the effects of
exercise on cells, tissues, and organs, which may initiate processes ultimately leading to
the health benefits of exercise. Because this is a mechanistic trial, the main goal is not a
health-related outcome. Rather, the goal is to generate a map of the molecular responses to
exercise that will be used by the Consortium and by the scientific community at large to
generate hypotheses for future investigations of the health benefits of PA.
Stanford is currently not accepting patients for this trial.
For more information, please contact SPECTRUM, .