Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

Pre-Registration Eligibility Criteria:

   - Clinical stage T1-3 N1 M0 breast cancer at diagnosis (prior to the start of
   neoadjuvant chemotherapy) by American Joint Committee on Cancer (AJCC) staging 7th
   edition

   - No inflammatory breast cancer

   - No other malignancy within 5 years of registration with the exception of basal cell or
   squamous cell carcinoma of the skin treated with local resection only or carcinoma in
   situ of the cervix

   - All patients must have had an axillary ultrasound with fine needle aspiration (FNA) or
   core needle biopsy of axillary lymph nodes documenting axillary metastasis at the time
   of diagnosis, prior to or at most 14 days after starting neoadjuvant chemotherapy

   * Note: Biopsy of intramammary nodes does not fulfill eligibility criteria

   - Patients must have had estrogen receptor, progesterone receptor and HER2 status (by
   immunohistochemistry [IHC] and/or in situ hybridization [ISH]) evaluated on diagnostic
   core biopsy prior to start of neoadjuvant chemotherapy

   * Note: If HER2 status has not been clearly determined (i.e. equivocal/indeterminate),
   then patients should not be enrolled

   - Patients must have completed all planned neoadjuvant chemotherapy prior to surgery;
   sandwich chemotherapy is not allowed (i.e. anthracycline/cytoxan or taxane
   chemotherapy planned to be given after surgery); patients must have completed at least
   4 cycles of neoadjuvant chemotherapy consisting of an anthracycline and/or
   taxane-based regimen without evidence of disease progression in the breast or the
   lymph nodes

   * Note: Delays/dose modifications due to toxicities/adverse events are allowed as long
   as a minimum of 4 cycles of neoadjuvant chemotherapy is administered; more than 4
   cycles of neoadjuvant chemotherapy (NAC) may be administered at the discretion of the
   treating medical oncologist

   - Patients with HER-2 positive tumors must have received neoadjuvant trastuzumab, or
   trastuzumab + pertuzumab, or other approved anti-HER-2 therapy (either with all or
   with a portion of the neoadjuvant chemotherapy regimen); therapy must be Food and Drug
   Administration (FDA)-approved targeted anti-HER2 therapy, but additional therapies are
   allowed as are non-trastuzumab regimens if administered in the context of an
   Institutional Review Board (IRB)-approved clinical trial

   - All patients must have a clinically negative axilla (no bulky adenopathy) on physical
   examination documented at the completion of neoadjuvant chemotherapy

   * Note: an ultrasound of the axilla is not required at completion of neoadjuvant
   chemotherapy; if performed, its findings do NOT impact eligibility

   - No more than 8 weeks of neoadjuvant endocrine therapy prior to the start of
   neoadjuvant chemotherapy

   - No neoadjuvant radiation therapy

   - No SLN surgery/excisional biopsy for pathological confirmation of axillary status
   prior to or during neoadjuvant chemotherapy

   - No prior history of ipsilateral breast cancer (invasive disease or ductal carcinoma in
   situ [DCIS]); lobular carcinoma in situ (LCIS) and benign breast disease is allowed

   - No prior ipsilateral axillary surgery, such as excisional biopsy of lymph node(s) or
   treatment of hidradenitis

   - No history of prior or concurrent contralateral invasive breast cancer; benign breast
   disease; LCIS or DCIS of contralateral breast is allowed

   - Patients must not be pregnant or nursing

   * Note: Peri-menopausal women must be amenorrheic for > 12 months to be considered not
   of childbearing potential

   - Eastern Cooperative Oncology Group (ECOG) (Zubrod) performance status 0-1

Intra-Operative Registration/Randomization Criteria:

   - Breast surgery (lumpectomy or mastectomy) and sentinel lymph node surgery must be
   completed within 56 days of the completion of the last dose of neoadjuvant
   chemotherapy

   - A minimum of 1 sentinel node and a maximum of 8 total nodes (sentinel + non-sentinel)
   are identified and excised; more than 8 nodes identified by either surgeon or
   pathologist is NOT allowed Note: Patients who do not have an identifiable sentinel
   lymph node will not proceed to registration/randomization

   - At least one lymph node (sentinel or non-sentinel) excised during sentinel lymph node
   surgery with a metastasis greater than 0.2 mm in greatest dimension identified on
   intra-operative pathologic assessment

      - Note: Isolated tumor cells (metastases less than or equal to 0.2 mm) will be
      treated as node negative disease (N0i+)

      - Note: If on final pathology, more than 8 lymph nodes are seen pathologically,
      then the patient should discontinue study

      - Axillary lymph node dissection (ALND) is not to be performed prior to
      registration/randomization

      - Note: Patients for whom no positive lymph nodes (sentinel or non-sentinel) are
      found during sentinel lymph node surgery will not proceed to
      registration/randomization and can be considered for discussion of the NRG NSABP
      B-51/RTOG 1304 study "A Randomized Phase III Clinical Trial Evaluating the Role
      of Post-mastectomy Chest Wall and Regional Nodal XRT and Post-lumpectomy Regional
      Nodal XRT in Patients with Documented Positive Axillary Nodes Before Neoadjuvant
      Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After
      Neoadjuvant Chemotherapy"

Post-Operative Registration/Randomization Criteria:

   - For cases where ALND has not been performed and one of the following is true: 1)
   intra-operative evaluation of sentinel lymph node could not be/was not performed and
   final pathology identified a positive lymph node (sentinel or non-sentinel) with
   metastasis greater than 0.2 mm OR 2) lymph node (sentinel or non-sentinel) considered
   negative on intra-operative evaluation was found to be positive on final pathology
   (with metastasis greater than 0.2 mm)

   - Breast surgery (lumpectomy or mastectomy) and sentinel lymph node surgery must be
   completed within 56 days of the completion of the last dose of neoadjuvant
   chemotherapy; negative margin (by either breast conservation or mastectomy) on final
   pathology where negative margin is defined as no tumor on ink

   - At least one lymph node (sentinel or non-sentinel) with a metastasis greater than 0.2
   mm in greatest dimension identified on final pathology (for cases where
   intra-operative evaluation was not performed, or was negative and completion
   dissection was not performed)

   - At least one and no more than 8 lymph nodes (sentinel and non-sentinel) were found by
   the pathologists to have been actually excised during sentinel lymph node procedure
   Note: Isolated tumor cells (metastases less than or equal to 0.2 mm) will be treated
   as node negative disease (N0i+)

   - For those patients who also undergo contralateral breast surgery, if invasive disease
   is found in the contralateral breast, the patient is not eligible for registration
   /randomization