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Exercise Study Including Patients With Hypertrophic Cardiomyopathy
Trial ID: NCT01165749
Purpose
The long term health and cardiovascular benefits of a regular exercise program have been
well-established. National guidelines recommend involvement in moderate aerobic fitness (i.e.
walking, bicycling, light jogging, swimming) for patients with hypertrophic cardiomyopathy
(HCM). However, data on potential benefits of recreational exercise, useful parameters for
risk stratification, and methods of devising individual exercise prescriptions are completely
lacking. The specific aims of this study are: 1) to devise a safe moderate intensity exercise
training program in patients with HCM, and 2) to determine whether exercise training improves
ability to perform activities and tasks, heart size and function, and quality of life in
patients with HCM.
Official Title
A Randomized Trial of Moderate Intensity Exercise Training in Patients With Hypertrophic Cardiomyopathy
Stanford Investigator(s)
Euan A. Ashley
Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
Eligibility
Inclusion Criteria:
1. Ages 18 - 80 years old.
2. Diagnosis of hypertrophic cardiomyopathy, defined by the presence of unexplained
left-ventricular hypertrophy (wall thickening) > 13 mm in any wall segment.
3. Exercise £ 30 minutes, 1 day per week for the previous 3 months.
4. Agreement to be a participant in the study protocol and willing/able to return for
follow-up.
Exclusion Criteria:
1. History of exercise-induced syncope or arrhythmias (ventricular tachycardia or
non-sustained ventricular tachycardia).
2. Medically refractory LV outflow tract obstruction being evaluated for septal reduction
therapy.
3. Less than 3 months post septal reduction therapy (surgery or catheter based
intervention).
4. Hypotensive response to exercise (> 20 mmHg drop in systolic blood pressure from peak
blood pressure to post exercise blood pressure).
5. Pregnancy.
6. ICD placement in last 3 months or scheduled.
7. Life expectancy less than 12 months.
8. Inability to exercise due to orthopedic or other non-cardiovascular limitations.
Intervention(s):
behavioral: stop exercising
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Lisa Garrett
650-736-7878