Feasibility 3D Perfusion Ultrasound for Liver Cancer SABR Planning and Response Evaluation

Inclusion Criteria:

* Ability to understand and willingness to sign the written informed consent document
* Patient with primary liver tumor or metastasis scheduled for Stereotactic Ablative Radiotherapy (SABR)
* Patient is at least 18 years of age. No gender/race-ethnic restrictions.
* Performance status (ECOG) between 0-3
* History and Physical done within 4 weeks of enrollment.

Exclusion Criteria:

* Patient has previously been enrolled in and completed this study.
* Known right to left cardiac shunt, bidirectional or transient.
* Patient has any medical condition or other circumstances which would significantly decrease the chances of obtaining reliable data, achieving study objectives, or completing the study and/or post-dose follow-up examinations.
* History of hypersensitivity to the contrast agent perflutren
* History of pulmonary hypertension
* Patients who are pregnant or are trying to become pregnant