Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis

Recruiting

I'm Interested

Trial ID: NCT01892839

Purpose

Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.

Official Title

Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis

Stanford Investigator(s)

Eligibility

Inclusion Criteria:

* stable on nocturnal in-center dialysis located close to Stanford University and VA Palo Alto

Exclusion Criteria:

* recent use of antibiotics
* gastrointestinal disease

Intervention(s):

other: low dialysate flow, smaller dialyzer

other: high dialysate flow, larger dialyzer

Recruiting

I'm Interested

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Timothy Meyer, MD
650-852-3314