Investigating HepQuant DuO Test as a Biomarker in Alcohol-related Liver Disease

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Trial ID: NCT07060547

Purpose

This is a study to measure liver recovery in patients with recent alcohol-associated liver injury by assessing liver function and physiology using HepQuant DuO. The HepQuant DuO Test is a blood-based test that involves a drink of a natural compound, cholate, and 2 blood samples at 20 and 60 minutes. The study team is collecting clinical and laboratory data to better monitor and treat patients who have been affected by alcohol-associated liver disease. The study has 4 visits at an outpatient clinic at 1, 3, 6, and 12 months. At each of these visits, participants will undergo a HepQuant DuO test and other standard tests. In addition, the study team will ask about a participant's alcohol use, symptoms, and quality of life.

Official Title

Investigating HepQuant DuO Test as a Biomarker in Alcohol-related Liver Disease

Stanford Investigator(s)

Allison Kwong

Assistant Professor of Medicine (Gastroenterology and Hepatology) and, by courtesy, of Surgery (Abdominal Transplantation)

Eligibility

Inclusion Criteria:

* adult with a clinical diagnosis of liver disease due to alcohol who have acute hepatic decompensation.

adult with a combined clinical diagnosis of alcohol-related liver disease (ALD) and nonalcoholic steatohepatitis (NASH).

Exclusion Criteria:

* Clinical diagnosis of liver disease with an etiology other than alcohol liver disease unless it is a combined clinical diagnosis of ALD and NASH.
* patients with solid organ malignancy.
* patients with other disease affecting the liver including autoimmune, drug-related liver injury, hemochromatosis or Wilson's disease
* pregnancy
* under the age of 18

Intervention(s):

device: HepQuant DuO Test

Recruiting

I'm Interested

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Ethan Assistant Clinical Research Coordinating Associate, BA
650-460-6119