Measured Hypocretin Levels and Recovery After Hip Surgery

Trial ID: NCT01009710


A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.

Official Title

Preoperative Cerebrospinal Fluid (CSF) Levels of Hypocretin and Recovery After Hip Surgery With Combined Spinal and General Anesthesia

Stanford Investigator(s)

Anthony G. Doufas, M.D., Ph.D.
Anthony G. Doufas, M.D., Ph.D.

Professor of Anesthesiology, Perioperative and Pain Medicine


Inclusion Criteria:- Adult (18 years of age or older)

   - Male or female

   - Scheduled for elective total hip arthroplasty at the Stanford Orthopedic Clinic.

   - Comprehend spoken and written English Exclusion Criteria:- ASA physical status > III
   (patients with severe systemic disease)

   - Diagnosed psychiatric disease (except mild depression)

   - Any diagnoses CNS disease or dementia

   - History of stroke

   - History of untreated thyroid disease

   - Difficulty in airway management (ventilation and/or intubation)

   - Body Mass Index (BMI) > 35 kg/m2

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Kevin Padrez