Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas

Inclusion Criteria:

   - Parts A & C: patients must be >= 12 months and < 18 years of age at the time of study
   enrollment

   - Parts B1-B6, B8, D1-D6, E3, E4: patients must be >= 12 months and =< 30 years of age
   at the time of study enrollment

   - Part B7: patients must be >= 12 months and < 18 years of age at the time of study
   enrollment

   - Patients must have had histologic verification of malignancy at original diagnosis or
   relapse

      - Parts A & C: patients with recurrent or refractory solid tumors, without central
      nervous system (CNS) tumors or known CNS metastases, are eligible; note: CNS
      imaging for patients without a known history of CNS disease is only required if
      clinically indicated

      - Part B1: patients with relapsed or refractory neuroblastoma

      - Part B2: patients with relapsed or refractory osteosarcoma

      - Part B3: patients with relapsed or refractory rhabdomyosarcoma

      - Part B4: patients with relapsed or refractory Ewing sarcoma or peripheral
      primitive neuroectodermal tumor (PNET)

      - Part B5: patients with relapsed or refractory Hodgkin lymphoma

      - Part B6: patients with relapsed or refractory non-Hodgkin lymphoma

      - Part B7: patients with unresectable melanoma or metastatic melanoma or relapsed
      melanoma or refractory melanoma

      - Part B8: Patients with relapsed or refractory neuroblastoma (MIBG evaluable
      disease without Response Evaluation Criteria in Solid Tumors [RECIST] measurable
      lesion)

      - Once the dose-escalation portion of Part A is completed, cohorts that are open
      concurrently for eligible patients (including Parts B and C and potential
      pharmacokinetic [PK] expansion cohorts) may be selected at the treating
      physician's discretion pending slot availability; in the event a disease group
      cohort in Part B is completed after the initial stage of Simon's optimal
      two-stage design, for selected disease cohorts, a corresponding cohort in the
      same disease group for select disease types will be open in Part D:

      - Part D1: Patients with relapsed or refractory neuroblastoma

      - Part D2: Patients with relapsed or refractory osteosarcoma

      - Part D3: Patients with relapsed or refractory rhabdomyosarcoma

      - Part D4: Patients with relapsed or refractory Ewing sarcoma or peripheral PNET

      - Part D5: Patients with relapsed or refractory non-Hodgkin lymphoma

      - Part D6: Patients with relapsed or refractory neuroblastoma (MIBG evaluable
      disease without RECIST measurable lesion)

      - Part E3: Patients with relapsed or refractory rhabdomyosarcoma

      - Part E4: Patients with relapsed or refractory Ewing sarcoma or peripheral PNET

   - Parts A & C: patients must have either measurable or evaluable disease

   - Parts B, D & E: patients must have measurable disease for Parts B1-B6, D1-D5, E3 and
   E4; melanoma patients in Part B7 must have either measurable or evaluable disease;
   neuroblastoma patients in Parts B8 and D6 must be evaluable for MIBG response without
   evidence of RECIST measurable lesions

   - Patient's current disease state must be one for which there is no known curative
   therapy or therapy proven to prolong survival with an acceptable quality of life

   - Karnofsky >= 50% for patients > 16 years of age and Lansky >= 60 for patients =< 16
   years of age; patients who are unable to walk because of paralysis, but who are up in
   a wheelchair, will be considered ambulatory for the purpose of assessing the
   performance score

   - Patients must have fully recovered from the acute toxic effects of all prior
   anti-cancer therapy and must meet the following minimum duration from prior
   anti-cancer directed therapy prior to enrollment; if after the required timeframe, the
   defined eligibility criteria are met, e.g. blood count criteria, the patient is
   considered to have recovered adequately

      - Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive

         - At least 21 days after the last dose of cytotoxic or myelosuppressive
         chemotherapy (42 days if prior nitrosourea)

      - Hematopoietic growth factors: At least 14 days after the last dose of a
      long-acting growth factor (e.g. pegfilgrastim) or 7 days for short-acting growth
      factor; for agents that have known adverse events occurring beyond 7 days after
      administration, this period must be extended beyond the time during which adverse
      events are known to occur; the duration of this interval must be discussed with
      the study chair

      - Anti-cancer agents not known to be myelosuppressive (e.g. not associated with
      reduced platelet or absolute neutrophil count [ANC] counts): At least 7 days
      after the last dose of agent

      - Interleukins, interferons and cytokines (other than hematopoietic growth
      factors): >= 21 days after the completion of interleukins, interferon or
      cytokines (other than hematopoietic growth factors)

      - Antibodies: >= 21 days must have elapsed from infusion of last dose of antibody,
      and toxicity related to prior antibody therapy must be recovered to grade =< 1

      - External beam radiation therapy (XRT)/external beam irradiation including
      protons: >= 14 days after local XRT; >= 150 days after total body irradiation
      (TBI), craniospinal XRT or if radiation to >= 50% of the pelvis; >= 42 days if
      other substantial bone marrow (BM) radiation.

      - Radiopharmaceutical therapy (e.g., radiolabeled antibody, 131I-MIBG): >= 42 days
      must have elapsed since systemically administered radiopharmaceutical therapy

      - Cellular therapy: >= 42 days must have elapsed since the completion of any type
      of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic
      cells, etc.)

      - Patients must not have received prior exposure to nivolumab; for patients
      enrolled in Parts C, D, and E patients must not have received prior nivolumab or
      ipilimumab

   - For patients with solid tumors without known bone marrow involvement:

   - Peripheral absolute neutrophil count (ANC) >= 750/mm^3

   - Platelet count >= 75,000/mm^3 (transfusion independent, defined as not receiving
   platelet transfusions for at least 7 days prior to enrollment)

   - Patients with known bone marrow metastatic disease will be eligible for study provided
   they meet the blood counts above (may receive transfusions provided they are not known
   to be refractory to red cell or platelet transfusions); these patients will not be
   evaluable for hematologic toxicity; at least 5 of every cohort of 6 patients with a
   solid tumor must be evaluable for hematologic toxicity, for Parts A and C; if
   dose-limiting hematologic toxicity is observed on either Part A or C, all subsequent
   patients enrolled must be evaluable for hematologic toxicity on that Part

   - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
   ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:

      - Age 1 to < 2 years: maximum serum creatinine (mg/dL) 0.6 for males and females

      - Age 2 to < 6 years: 0.8 for males and females

      - Age 6 to < 10 years: 1 for males and females

      - Age 10 to < 13 years: 1.2 for males and females

      - Age 13 to < 16 years: 1.5 for males and 1.4 for females

      - Age >= 16 years: 1.7 for males and 1.4 for females

   - Bilirubin (sum of conjugated + unconjugated) =< 1.5 x upper limit of normal (ULN) for
   age

   - Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 135
   U/L; for the purpose of this study, the ULN for SGPT is 45 U/L

   - No evidence of dyspnea at rest, no exercise intolerance due to pulmonary
   insufficiency, and a pulse oximetry > 92% while breathing room air

   - Serum lipase =< ULN at baseline; patients with glucose intolerance should be on a
   stable regimen and be monitored

   - All patients and/or their parents or legally authorized representatives must sign a
   written informed consent; assent, when appropriate, will be obtained according to
   institutional guidelines

   - Tissue blocks or slides must be sent for all patients; if tissue blocks or slides are
   unavailable, the study chair must be notified prior to enrollment

Exclusion Criteria:

   - Pregnant or breast-feeding women will not be entered on this study due to risks of
   fetal and teratogenic adverse events as there is yet no available information
   regarding human fetal or teratogenic toxicities; pregnancy tests must be obtained in
   girls who are post-menarchal; women of childbearing potential (WOCBP) receiving
   nivolumab will be instructed to adhere to contraception for a period of 5 months after
   the last dose of nivolumab; men receiving nivolumab and who are sexually active with
   WOCBP will be instructed to adhere to contraception for a period of 7 months after the
   last dose of nivolumab

   - Patients requiring daily systemic corticosteroids are not eligible; patients must not
   have received systemic corticosteroids within 7 days prior to enrollment; if used to
   modify immune adverse events related to prior therapy, >= 14 days must have elapsed
   since last dose of corticosteroid; Note: use of topical or inhaled corticosteroids
   will not render a patient ineligible

   - Patients who are currently receiving another investigational drug are not eligible

   - Patients who are currently receiving other anti-cancer agents are not eligible

   - Patients with CNS tumors or known CNS metastases will be excluded from this trial;
   patients with a history of CNS metastases that have been previously treated may enroll
   if sequential imaging shows not evidence for active disease; patients with extra axial
   disease (e.g. skull [bone] metastasis that do not invade the dura) may enroll if there
   is no evidence for CNS edema associated with the lesion

   - Patients with a history of any grade autoimmune disorder are not eligible;
   asymptomatic laboratory abnormalities (e.g. antinuclear antibody [ANA], rheumatoid
   factor, altered thyroid function studies) will not render a patient ineligible in the
   absence of a diagnosis of an autoimmune disorder

   - Patients with >= grade 2 hypothyroidism due to history of autoimmunity are not
   eligible; note: hypothyroidism due to previous irradiation on thyroidectomy will not
   impact eligibility

   - Patients who have an uncontrolled infection are not eligible

   - Patients with a history of congestive heart failure (CHF) or are at risk because of
   underlying cardiovascular disease or exposure to cardiotoxic drugs must have adequate
   cardiac function as clinically indicated:

      - Corrected QT interval (QTC) =< 480 msec

      - Shortening fraction of >= 27% by echocardiogram or ejection fraction of >= 50% by
      gated radionuclide study

   - Patients with known human immunodeficiency virus (HIV) or hepatitis B or C are
   excluded

   - Patients who have received prior solid organ transplantation are not eligible

   - Patient who have received allotransplantation are not eligible

   - Patients who in the opinion of the investigator may not be able to comply with the
   safety monitoring requirements of the study are not eligible

   - Patients who have received prior anti-PD1 directed therapy (monoclonal antibody [mAb]
   or small molecule) are not eligible

   - Parts C, D, and E: patients who have received prior ipilimumab are not eligible