Peripheral Immune System in Individuals With Schizophrenia

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Trial ID: NCT05109065

Purpose

The investigators are seeking healthy volunteers and people with schizophrenia or schizoaffective disorder for a clinical study of the immune system in psychotic disorders. This is an observational study, to understand the ways in which the immune system may be contributing to the disease process.

Official Title

Peripheral Immune System in Individuals With Schizophrenia

Stanford Investigator(s)

Eligibility

Inclusion Criteria for Subjects with schizophrenia and schizoaffective disorders:

* Schizophrenia or schizoaffective disorder diagnosis verified by interview
* Diagnosis or initiation of antipsychotic medication was within last 5 years

Inclusion Criteria for Healthy Controls:

* No known diagnosis of schizophrenia or schizoaffective disorder
* No history of depression, anxiety, bipolar disorder, PTSD, agoraphobia, panic disorder, or generalized anxiety disorder
* Negative assessment for psychotic symptoms on day of interview

Exclusion Criteria (for both groups):

* Participants have a history of bleeding disorders or are taking blood thinners.
* Participants have a history of epilepsy, known genetic disorders
* Immunocompromised state (eg., receiving immunosuppressive therapy, transplant).
* History of brain-related disease (eg., stroke)
* Any uncontrolled medical disorder such as cancer.
* History of substance abuse or positive urine toxicology screen (including test for marijuana) on the day of the blood draw

Intervention(s):

diagnostic_test: SCID (Standardized Clinical Interview for DSM-V)

diagnostic_test: PSS (Perceived Stress Score)

diagnostic_test: Urine Toxicology Screen

diagnostic_test: Vitals

diagnostic_test: Blood Work

diagnostic_test: PQ-B

diagnostic_test: COVID Screening

diagnostic_test: Positive and Negative Syndrome Scale (PANSS)

Recruiting

I'm Interested

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Diane E Wakeham, PhD
650-736-5243