Therapy for Pediatric Hodgkin Lymphoma

Inclusion Criteria:

   - Eligible patients must have histologically confirmed previously untreated Hodgkin's
   disease (Patients receiving limited emergent RT or steroid therapy because of
   cardiopulmonary decompensation or spinal cord compression will be eligible for
   protocol enrollment).

   - Patients must be 21 years of age or younger

   - Ann Arbor stages IIB-IV

   - No prior treatment.

   - No pregnant or lactating women.

   - Signed informed consent

   - If re-evaluation of a patient's disease shows favorable risk features or intermediate
   risk features, the patient will be removed from the HOD99 study and consented to the
   respective HOD08 or HOD05 study.

Inclusion: treatment of favorable risk features:

   - Ann Arbor IA or IIA with:

      1. Non-bulky mediastinal disease (<33% mediastinal to thoracic ratio on chest x ray)

      2. Ann Arbor stage IA or IIA with any of the following features: (1) "E" lesions
      (s), (2) 3 or more nodal sites involved, (3) Bulky mediastinal adenopathy
      (mediastinal mass to thoracic cavity ratio 33% or greater by chest radiograph)

      Inclusion: unfavorable risk features:

   - Stage must be classified as one of the following:

      1. Ann Arbor stage IIB, IIIB, or any IV