TMS for Complex Regional Pain Syndrome


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Trial ID: NCT03137472


The aim of the current study is to assess the efficacy of TMS in the treatment of Complex Regional Pain Syndrome (CRPS). It is hypothesized that participants who receive TMS (Group 1) relative to sham treatment (Group 2) once daily for two days will demonstrate a greater improvement in CRPS-related pain and other associated symptomology (i.e., cognitive, emotional and physical) compared to baseline. Participants will be followed until they reach their baseline for two consecutive weeks to assess safety and duration of symptom alleviation.

Official Title

Transcranial Magnetic Stimulation (TMS) for Complex Regional Pain Syndrome (CRPS)

Stanford Investigator(s)

Sean Mackey, M.D., Ph.D.
Sean Mackey, M.D., Ph.D.

Redlich Professor, Professor of Anesthesiology, Perioperative, and Pain Medicine and, by courtesy, of Neurology


Inclusion Criteria:

   - Age 18-70

   - Diagnosis of CRPS (complex regional pain syndrome) for at least 3 months

   - Average pain level reported on Numerical Rating Scale meets entry criteria

   - Ability to perform the experimental task and procedures.

Exclusion Criteria:

   - MRI contraindication (metal implants or devices, claustrophobia)

   - TMS Contraindication (eg metal implant or devices near the site of stimulation)

   - History of epilepsy

   - History of a psychological or psychiatric disorder that would interfere with study
   procedures, at the discretion of the researcher.

   - Neurologic illness that would interfere with brain integrity

   - Current medical condition or medication use that would interfere with study procedures
   or data integrity, at the discretion of the researcher.

   - Currently pregnant or planning to become pregnant.

   - On going legal action or disability claim.


device: Transcranial Magnetic Stimulation (TMS)


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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Kristen H Scherrer