The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis

Not Recruiting

Trial ID: NCT03467919


This is a non-surgical trial comparing the clinical and functional outcomes of patients with osteoarthritis treated with Intra-articular injection of Micro Fragmented Adipose Tissue versus conventional therapy of intra-articular injection of corticosteroid.

Official Title

The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis

Stanford Investigator(s)

Seth Lawrence Sherman, MD
Seth Lawrence Sherman, MD

Associate Professor of Orthopaedic Surgery

Eugene Y. Roh, MD
Eugene Y. Roh, MD

Clinical Associate Professor, Orthopaedic Surgery


Inclusion Criteria:

   - Age between 35 and 75 years-old

   - Diagnosis of pre-existing osteoarthritis of the joint by Kellgren-Lawrence Grade 2 or

   - Working understanding of the English language and able to fully understand the

   - Capable of providing informed consent

   - Able to complete online, in-person or phone surveys for the purposes of follow-up

   - Capable of understanding pre- and post-procedure care instructions

   - Ambulatory at baseline

   - Previous trial and failure of conservative therapy consisting of a minimum of 6 weeks
   of physical therapy and trial of anti-inflammatory medications if not contraindicated,
   with or without concomitant bracing and/or injections.

Exclusion Criteria:

   - Age < 35 or > 75 years old

   - Radiographs demonstrating either no, little or severe osteoarthritis
   (Kellgren-Lawrence Grade 0, 1 )

   - Prior total or partial joint replacement surgery or a surgery involving cartilage
   regeneration (microfracture, ACI, etc)

   - Previous cortisone and/or Hyaluronic acid intra-articular injection within the last 3

   - Co-morbidity with rheumatologic condition, inflammatory arthritis

   - Currently undergoing immunomodulatory therapy

   - Uncontrolled endocrine disorder

   - BMI >35

   - Current diagnosis of osteomyelitis, human immunodeficiency virus (HIV-1, -2) and/or
   hepatitis C (HCV), infection and poorly controlled diabetes (HgA1C >7.0)

   - Pregnancy or planned pregnancy

   - previous stem cell injection into treatment joint

   - Patient scheduled to undergo any concomitant surgical procedures.

   - Coagulopathy or anticoagulant treatment

   - Chronic pain involving multiple body parts or opioid medication management


biological: Micro Fragmented Adipose Tissue

biological: Corticosteroid injection

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Eugene Y Roh, MD