The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI

Not Recruiting

Trial ID: NCT03883308

Purpose

The purpose of this study is to integrate advanced computational techniques and multimodal neuroimaging methods to examine the potential effects of long-term, multi-domain, online, computerized cognitive training on large-scale structural and functional brain networks in older adults with mild cognitive impairment (MCI).

Official Title

The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI

Stanford Investigator(s)

Eligibility

Inclusion criteria:

* Cognitive concern by subject, informant or physician
* Impairment in memory domain (delayed recall of one paragraph from Logical Memory II subscale from Wechsler memory Scale - Revised with cutoff scores of \<=8, \<=4 and \<=2 for 16, 8-15 and 0-7 years of education)
* Essentially normal functional activities
* Mini-Mental State Examination (MMSE) scores \>=24
* Stability of permitted medications (e.g. cholinesterase inhibitors, hypertension medication, etc.) for at least two months.

Exclusion criteria:

* Any significant neurological condition including probable dementia, Parkinson's disease, Huntington's disease, multiple sclerosis, and brain tumor, among others.
* Presence of Axis I disorder
* Current use of psychoactive medications except for the permitted medications.
* Claustrophobia
* MRI contraindication
* Any significant systemic or unstable medical condition which could lead to difficulty complying with the protocol.

Intervention(s):

behavioral: Multi-domain cognitive training

behavioral: Cross-word puzzle training

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Hadi Hosseini, PhD
650-724-2939