The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI

Inclusion criteria:

* Cognitive concern by subject, informant or physician
* Impairment in memory domain (delayed recall of one paragraph from Logical Memory II subscale from Wechsler memory Scale - Revised with cutoff scores of \<=8, \<=4 and \<=2 for 16, 8-15 and 0-7 years of education)
* Essentially normal functional activities
* Mini-Mental State Examination (MMSE) scores \>=24
* Stability of permitted medications (e.g. cholinesterase inhibitors, hypertension medication, etc.) for at least two months.

Exclusion criteria:

* Any significant neurological condition including probable dementia, Parkinson's disease, Huntington's disease, multiple sclerosis, and brain tumor, among others.
* Presence of Axis I disorder
* Current use of psychoactive medications except for the permitted medications.
* Claustrophobia
* MRI contraindication
* Any significant systemic or unstable medical condition which could lead to difficulty complying with the protocol.