The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI

Inclusion criteria:

   - Cognitive concern by subject, informant or physician

   - Impairment in memory domain (delayed recall of one paragraph from Logical Memory II
   subscale from Wechsler memory Scale - Revised with cutoff scores of <=8, <=4 and <=2
   for 16, 8-15 and 0-7 years of education)

   - Essentially normal functional activities

   - Mini-Mental State Examination (MMSE) scores >=24

   - Stability of permitted medications (e.g. cholinesterase inhibitors, hypertension
   medication, etc.) for at least two months.

Exclusion criteria:

   - Any significant neurological condition including probable dementia, Parkinson's
   disease, Huntington's disease, multiple sclerosis, and brain tumor, among others.

   - Presence of Axis I disorder

   - Current use of psychoactive medications except for the permitted medications.

   - Claustrophobia

   - MRI contraindication

   - Any significant systemic or unstable medical condition which could lead to difficulty
   complying with the protocol.