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The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI
Not Recruiting
Trial ID: NCT03883308
Purpose
The purpose of this study is to integrate advanced computational techniques and multimodal
neuroimaging methods to examine the potential effects of long-term, multi-domain, online,
computerized cognitive training on large-scale structural and functional brain networks in
older adults with mild cognitive impairment (MCI).
Official Title
The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI
Stanford Investigator(s)
Eligibility
Inclusion criteria:
- Cognitive concern by subject, informant or physician
- Impairment in memory domain (delayed recall of one paragraph from Logical Memory II
subscale from Wechsler memory Scale - Revised with cutoff scores of <=8, <=4 and <=2
for 16, 8-15 and 0-7 years of education)
- Essentially normal functional activities
- Mini-Mental State Examination (MMSE) scores >=24
- Stability of permitted medications (e.g. cholinesterase inhibitors, hypertension
medication, etc.) for at least two months.
Exclusion criteria:
- Any significant neurological condition including probable dementia, Parkinson's
disease, Huntington's disease, multiple sclerosis, and brain tumor, among others.
- Presence of Axis I disorder
- Current use of psychoactive medications except for the permitted medications.
- Claustrophobia
- MRI contraindication
- Any significant systemic or unstable medical condition which could lead to difficulty
complying with the protocol.
Intervention(s):
behavioral: Multi-domain cognitive training
behavioral: Cross-word puzzle training
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Hadi Hosseini, PhD
650-724-2939