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Trial ID: NCT01413516
A Two-Part Pilot Study of Dosing, Safety and Efficacy of Varenicline Initiated During an Acute Smoke-free Hospitalization and Continued Post-Hospitalization
Senior Associate Vice Provost, Clinical Research Governance and Professor of Medicine (Stanford Prevention Research Center)
- The sample, 40 women and 40 men, will be hospitalized patients recruited from Stanford
Hospital and Clinics who report smoking at least 10 cigarettes per day prior to
hospitalization, have confirmed tobacco use by cotinine testing, and an expected
hospitalization of at least 3 days duration from the date of study enrollment.
Intention to quit smoking will not be required for study participation.
- Study exclusion criteria are: dementia or other brain injury precluding ability to
participate; Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; meningitis;
seizure disorder of a sustained nature; delirium; brain surgery; drug and/or alcohol
dependence; suicidal ideation; end-stage renal disease (i.e., on dialysis); hypertensive
crisis; stroke; myocardial infarction (MI) with severe cardiac damage; pregnancy or
breastfeeding; non-English speaking; complete homelessness; or currently engaged in tobacco
treatment. Study staff will consult with clinical staff prior to approach for study
enrollment. In cases of severe renal impairment (estimated creatinine clearance <30
mL/min), medical staff will consult with participants' physician to assess the
appropriateness for study enrollment.
behavioral: Smoking cessation counseling
School of Medicine
300 Pasteur Drive
Stanford, CA 94305