Trial Search Results
An Open-Label Trial of Donepezil in Fragile X Syndrome
Fragile X syndrome is the most common known inherited cause of neurodevelopmental disability. Functional magnetic resonance imaging (fMRI) studies from our laboratory indicate that specific brain regions using the neurochemical, acetylcholine, show significantly reduced activation during learning. Since donepezil is a medication that enhances acetylcholine function in the brain, the purpose of this study is to determine if donepezil has any beneficial effect on behavior or cognition in subjects with fragile X syndrome.
Stanford is currently not accepting patients for this trial.
- Drug: donepezil
Inclusion Criteria:1. Confirmed genetic diagnosis of fragile X syndrome
2. Age e 14
3. Verbal IQ e 60 Exclusion Criteria:1. Currently taking any anticholinergic medications,
tricyclic antidepressant medications, or diphenhydramine.
2. Presence of cardiac disease or bradycardia (< 60 beats/minute) at initial evaluation.
Ages Eligible for Study
14 Years - N/A
Genders Eligible for Study