Trial Search Results

Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

We would like to test the effect of opioid medication on pain sensitivity in subjects who have been diagnosed with a sleep disorder called Obstructive Sleep Apnea (OSA) compared to other subjects without OSA. Patients with OSA may have an altered sensitivity to the sedative, analgesic, and respiratory depressant effects of opioids.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):


  • Drug: Remifentanil
  • Procedure: Cold pain threshold and tolerance
  • Device: Heat pain threshold and tolerance
  • Procedure: Polysomnography


Inclusion Criteria:1. Male 2 .18 - 55 years of age 3. Body mass index (BMI) lower or equal
to 30 kg/m2 4. Absence of severe systemic disease that results in functional limitations
(i.e. poorly controlled hypertension, angina pectoris, prior myocardial infarction,
pulmonary disease that limits activity) 5.Subjects must be able to comprehend spoken and
written English

Exclusion Criteria:1. Major psychiatric, neurological, or neuromuscular disorder 2. Known
diabetes mellitus or thyroid disease 3. Allergy to study medication (remifentanil) 4.
History of addiction 5. Alcohol consumption which exceeds 2 drinks per day and /or drug
abuse. 6. Chronic or acute use of opioids, or other medications affecting the CNS.

Ages Eligible for Study

18 Years - 55 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305