Trial Search Results

A Phase II Study of GSK1363089 (Formerly XL880) for Papillary Renal-Cell Carcinoma (PRC)

This clinical study is being conducted at multiple sites to determine the best confirmed response rate, safety, and tolerability of GSK1363089 treatment in papillary renal cell carcinoma. Papillary renal cell carcinoma may be classified into hereditary and sporadic forms; subjects with either classification will be accepted into this study.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:


Stanford Investigator(s):


  • Drug: foretinib (formerly GSK1363089 or XL880)


Phase 2


Inclusion Criteria:

   - Histologically confirmed diagnosis of PRC with metastatic disease or bilateral
   multifocal renal tumors localized to kidneys. Measurable disease, ECOG performance
   status of
   - Adequate bone marrow reserve, hepatic, renal, and cardiovascular function.

Exclusion Criteria:

   - Radiation to >/=25% of bone marrow within 14 days of GSK1363089, more than 1 prior
   anti-cancer therapy, received prior treatment with a c-met inhibitor, brain

   - Any uncontrolled intercurrent illness,

   - Pregnant or breastfeeding,

   - HIV positive

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Denise Haas
Not Recruiting