Trial of Aripiprazole in Trichotillomania

Inclusion Criteria:

Eligible patients:

   - Must be outpatients between the ages of 18 and 65 at the start of study

   - May be male or female

   - Have DSM-IV trichotillomania of at least 6 months duration

   - Allowed psychotropic medications are limited to:

      - SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine,
      sertraline), SNRIs (duloxetine, venlafaxine) and mirtazapine, as long as the
      dosage has not changed for 4 weeks prior to study enrollment.

      - Other allowed medications include non-hypnotic sleeping agents, specifically
      trazodone, diphenhydramine, hydoxyzine and ramelteon.

      - If a patient is taking non-allowed psychotropic medications, he/she must be
      titrated off by the prescribing physician and be off of the medication for at
      least 2 weeks prior to trial enrollment.

   - We will not exclude patients meeting DSM-IV criteria for:

      - body dysmorphic disorder;

      - major depression;

      - dysthymia;

      - GAD, social phobia, panic disorder.

Exclusion Criteria:

   - We will exclude patients suffering from:

      - organic mental disorders;

      - psychotic mental disorders including delusional disorder, somatic type;

      - mental retardation or developmental disabilities;

      - substance or alcohol abuse;

      - depressive disorders with current suicidal risk;

      - factitious disorders;

      - dissociative disorders;

      - obsessive compulsive disorder;

      - personality disorders sufficiently severe to interfere with cooperation with the
      study;

      - bipolar I or II disorder.

   - Patients taking psychotropic agents other than those specifically listed in item d
   above. If a patient is taking non-allowed psychotropic medications, he/she must be
   titrated off such medications by the prescribing physician and be off of the
   medication for 2 weeks prior to trial enrollment.

   - Pregnant or nursing women.

   - Patients with a known hypersensitivity or allergy to aripiprazole.