FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT

Inclusion Criteria:

   1. Patients with

      - stable angina or,

      - stabilized angina pectoris or,

      - atypical chest pain or no chest pain but with documented silent ischemia

   2. at least one stenosis is present of at least 50% in one major native epicardial
   coronary artery and supplying viable myocardium

   3. Eligible for PCI

   4. Signed written informed consent

Exclusion Criteria:

   1. Patients in whom the preferred treatment is CABG

   2. Patients with left main coronary artery disease requiring revascularization

   3. Patients with a recent STEMI or Non-STEMI

   4. Prior CABG

   5. Contra-indication to dual antiplatelet therapy

   6. LVEF < 30%

   7. Severe LV hypertrophy

   8. Planned need for concomitant cardiac surgery

   9. Extremely tortuous or calcified coronary arteries precluding FFR measurements

10. A life expectancy of less than 2 years

11. Age under 21