Trial Search Results

Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement

You are invited to participate in a research study assessing your mental status in the first days after your surgery and how you will be doing in the 2 years following the surgery. The investigators hope to learn more about the incidence of postoperative confusion and a possible relation with 2 anesthesia techniques that are routinely used. The first one is an anesthesia technique that uses the inhaled anesthetic gas desflurane and the second one is an anesthesia technique that uses the anesthetic propofol administered by infusion in a vein. The investigators are also looking to see if there is a relationship between anesthesia technique and cardiovascular outcomes. You were selected as a possible participant in this study because at your age this phenomenon appears to have a greater incidence.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Pedro Paulo Tanaka

Collaborator: Baxter Healthcare Corporation

Stanford Investigator(s):


  • Drug: propofol
  • Drug: Desflurane


Phase 4


Inclusion Criteria:

   - Age > 65 years old

   - Body mass index > 30 kg/m2

   - Undergoing primary total knee arthroplasty surgery

   - American society of anesthesiology classification II-III

Exclusion Criteria:

   - Patient refusal to participate in the study

   - Patient refusal or failure of regional block

   - Patients with preexisting neuro-cognitive disorders

   - Known intolerance to any of the drugs to be used according to the study protocol

Ages Eligible for Study

65 Years - N/A

Genders Eligible for Study


Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Pedro Tanaka