Chemotherapy Based on PET Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma

Inclusion Criteria:

   - Histologically proven classical Hodgkin lymphoma subclassified according to the World
   Health Organization (WHO) Classification of Tumors, 4th edition (2008)

   - Patients must have clinical stage IA, IB, IIA, or IIB disease

      - Patients with "E" extensions will be eligible if all other criteria have been met

   - Patients must have a mediastinal mass > 0.33-cm maximum intrathoracic diameter on
   standing postero-anterior chest x-ray or measuring > 10 cm in its largest diameter on
   axial CT images

   - Bone marrow biopsy is required

   - ECOG performance status 0-2

   - ANC ≥ 1,000/μL

   - Platelet count ≥ 100,000/μL

   - Hemoglobin ≥ 10 g/dL

   - Serum creatinine ≤ 2 mg/dL

   - Direct bilirubin ≤ 2 mg/dL

   - AST/ALT ≤ 2 times upper limit of normal

   - Women of childbearing potential and sexually active males must be strongly advised to
   use an accepted and effective method of contraception

   - LVEF by ECHO or MUGA normal unless thought to be disease related

   - DLCO ≥ 60% with no symptomatic pulmonary disease unless thought to be disease related

   - Patients with a history of intravenous drug abuse, or any behavior associated with an
   increased risk of HIV infection, should be tested for exposure to the HIV virus, and
   an HIV test is required for entry on this protocol

   - HIV-positive patients are eligible if they have CD4 counts ≥ 400/mm³ and are on
   concurrent antiretrovirals

      - Patient HIV status must be known prior to registration

      - HIV-positive patients must not have multi-drug resistant HIV infections; CD4
      counts < 400/mm³; or other concurrent AIDS-defining conditions

   - Concurrent antiretroviral therapy for HIV-positive patients (CD4 counts ≥ 400/mm³)
   allowed

Exclusion Criteria:

   - Nodular lymphocyte-predominant Hodgkin lymphoma

   - Pregnant or nursing

   - "Currently active" second malignancy other than non-melanoma skin cancers

      - Patients are not considered to have a "currently active" malignancy if they have
      completed therapy and are considered by their physician to be at less than 30%
      risk of relapse

   - Prior treatment (chemotherapy or radiation therapy) for Hodgkin lymphoma