Trial Search Results

Assessing Response to Treatment in Non-Hodgkin's Lymphoma Patients Using 64Cu-DOTA-Rituximab PET/CT

Rituximab is an antibody targeted against the CD20 antigen found primarily on B-cells. Therefore, an imaging agent targeting CD20 expression may provide a more accurate evaluation of extent of disease and response to therapy than the current standard of care, F-18 FDG PET/CT.

The main purpose of the study is to investigate a new PET/CT imaging probe for detection and follow up of lymphoma. Following are the 3 aims of the study: a) Phase I testing in lymphoma patients of Cu-64 labelled Rituxan for defining normal tracer biodistribution, stability, pharmacokinetics and radiation dosimetry; b) comparison of Cu-64 Rituxan and F-18 FDG PET/CT in lymphoma patients; c) evaluation of changes in uptake of Cu-64 Rituxan in response to rituximab-based treatment in CD20-positive B-cell NHL

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Sanjiv Sam Gambhir

Stanford Investigator(s):


  • Drug: Cu-64 Rituximab




Inclusion Criteria:

   - Patients must have a diagnosis of CD20-positive B-cell NHL and a staging 18F FDG
   PET/CT prior to the 64Cu-DOTA-Rituximab PET/CT

   - Patients must understand and voluntarily sign an Informed Consent form after the
   contents have been fully explained to them

   - Patients must be scheduled for rituximab-based therapy

   - Patients must be older than 18-year-old

Exclusion Criteria:

   - Patients who cannot complete a PET/CT scan

   - Pregnant women

   - Patients participating in other research protocols will be excluded from this study

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting