A Study of Brain Aging in Vietnam War Veterans

Participants will be classified as either controls, TBI, or PTSD. General
Inclusion/Exclusion Criteria will apply to all groups, with specific criteria for each
group as described below.

Inclusion Criteria:

General (applies to each cohort):

   - Subjects must be Veterans of the Vietnam War, 50-90 years of age. (Subjects 60-80
   years of age will be selected first, while subjects <60 or >80 years of age will be
   added if recruitment numbers are too low in the 60-80 age range);

   - Must live within 150 miles of the closest ADNI clinic in subject's area.

Specific Inclusion Criteria for Controls:

   - Comparable in age, gender, and education with TBI and PTSD groups;

   - May be receiving Veterans Affairs (VA) disability payments for something other than
   TBI or PTSD - or no disability at all.

Specific Inclusion Criteria for TBI:

   - Subjects must have a documented history of moderate-severe non-penetrating TBI, which
   occurred during military service in Vietnam (identified from the Department of Defense
   or VA records);

   - TBI will be defined as:

      - Loss of consciousness,

      - Post-traumatic amnesia >24 hours, OR

      - Alteration of consciousness or mental state >24 hours

Specific Inclusion Criteria for PTSD:

   - Subjects who meet the Structured Clinical Interview 1 of the Diagnositic and
   Statistical Manual of Mental Disorders, Version IV, (Axis 1) - Text Revision [SCID-I
   of the DSM-IV-TR] criteria for current/chronic PTSD (identified by records, and
   verified by our telephone assessments);

   - In addition to meeting DSM-IV-TR criteria for current/chronic PTSD, subjects must have
   a minimum current Clinician Administered PTSD Scale (CAPS) score of 50 as determined
   by telephone assessment;

   - The PTSD symptoms contributing to the PTSD Diagnosis and Current CAPS score must be
   related to a Vietnam War related trauma.

Exclusion Criteria:

General (applies to each cohort):

   - MCI/dementia;

   - History of psychosis or bipolar affective disorder;

   - History of alcohol or substance abuse/dependence within the past 5 years (by DSM-IV-TR
   criteria) or a prior prolonged history of abuse;

   - MRI-related exclusions: aneurysm clips, metal implants that are determined to be
   unsafe for MRI; and/or claustrophobia;

   - Contraindications for lumbar puncture, PET scan, or other procedures in this study;

   - Any major medical condition must be stable for at least 4 months prior to enrollment.
   These include but are not limited to clinically significant hepatic, renal, pulmonary,
   metabolic or endocrine disease, cancer, HIV infection and AIDS, as well as
   cardiovascular disease, including:

      - cardiac surgery or myocardial infarction within the last 4 weeks;

      - unstable angina;

      - acute decompensated congestive heart failure or class IV heart failures;

      - current significant cardiac arrhythmia or conduction disturbance particularly
      those resulting in ventricular fibrillation, or causing syncope, or near syncope;

      - Uncontrolled high blood pressure

   - Seizure disorder or any systemic illness affecting brain function during the past 5
   years will be exclusionary;

   - Clinical evidence of stroke;

   - Have a history of relevant severe drug allergy or hypersensitivity;

   - Subjects with current clinically significant unstable medical comorbidities, as
   indicated by history or physical exam, that pose a potential safety risk to the
   subject.

Specific Exclusion Criteria for Controls:

• Exclusionary criteria applied to TBI/PTSD (outlined below) will be applied to controls.

Specific Exclusion Criteria for TBI:

• Presence of PTSD by SCID-I for DSM-IV-TR criteria, or a CAPS score of >30 (Both current
and/or a history of PTSD will be excluded).

Specific Exclusion Criteria for PTSD:

   - Documented or self report history of mild/moderate severe TBI;

   - Any history of head trauma associated with injury onset cognitive complaints; or

   - Loss of consciousness for >5 minutes.