Tofacitinib for the Treatment of Alopecia Areata and Its Variants

Inclusion Criteria:

   - Age >= 18 years old

   - Diagnosis of alopecia areata with >50% scalp involvement, alopecia totalis, or
   alopecia universalis

   - Hair loss present for at least 6 months

   - No treatment for alopecia areata in past 2 months

   - No evidence of hair regrowth

   - Females of childbearing potential must use birth control while taking the medication
   and there must be a negative pregnancy test documented prior to starting the
   medication

   - Fluent in spoken and written English

Exclusion Criteria:

   - Age <18 years old

   - Patients have received treatment known to affect alopecia areata within 2 months of
   enrolling in the study

   - Patients with a history of malignancy (except history of successfully treated basal
   cell or squamous cell carcinoma of the skin)

   - Patients known to be HIV or hepatitis B or C positive

   - Patients with positive tuberculin skin test or positive QuantiFERON TB test

   - Patients with leukopenia or anemia

   - Patients with renal or hepatic impairment

   - Patients with peptic ulcer disease

   - Patients taking immunosuppressive medications, including but not limited to
   prednisone, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus,
   cyclosporine, or TNH-alpha inhibitors

   - Women of childbearing potential who are unable or unwilling to use birth control while
   taking the medication

   - Women who are pregnant or nursing