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Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)
Not Recruiting
Trial ID: NCT02748070
Purpose
While oral steroids have been shown to be effective in the management of patients with
chronic rhinosinusitis with polyps, its role in treating chronic rhinosinusitis without
polyps (CRSsNP) is ambiguous. Despite a lack of strong clinical evidence to suggest a benefit
in this disease state, steroids are often prescribed as a component of post-operative care
after sinus surgery for patients without polyps. Oral steroids carry with them significant
adverse effects, and should be prescribed thoughtfully. The aims of this study are to
determine if oral steroids in the peri-operative period improves patient outcomes in CRS
without polyps.
Official Title
The Role of Perioperative Systemic Steroids in Patients With Chronic Rhinosinusitis Without Polyps (CRSsNP)
Stanford Investigator(s)
Michael Chang, MD
Assistant Professor of Otolaryngology - Head & Neck surgery (OHNS)
Eligibility
Inclusion Criteria:
- CRSsNP as defined by Clinical Practice Guideline (Update) on Adult Sinusitis
- scheduled to undergo endoscopic sinus surgery
Exclusion Criteria:
- chronic rhinosinusitis with polyps (CRSwNP)
- Aspirin exacerbated respiratory disease
- Cystic fibrosis
- Immunosuppressive states (Human immunodeficiency virus, transplant)
- Oral steroid use within 30 days of surgery
Intervention(s):
drug: Prednisone
drug: Flonase
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Peter H Hwang, M.D.
650-725-6500