©2022 Stanford Medicine
DCM Precision Medicine Study
Not Recruiting
Trial ID: NCT03037632
Purpose
The aims of the DCM Precision Medicine Study are to test the hypothesis that DCM has
substantial genetic basis and to evaluate the effectiveness of a family communication
intervention in improving the uptake and impact of family member clinical screening.
Official Title
Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry
Stanford Investigator(s)
Euan A. Ashley
Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
Eligibility
Inclusion Criteria:
- Meeting criteria for dilated cardiomyopathy (DCM) :
- Left ventricular ejection fraction <50%
- Left ventricular enlargement (A left ventricular end-diastolic dimension >
95%tile population standard based on gender and height).
- Detectable causes of cardiomyopathy, except genetic, excluded beyond a reasonable
doubt at the time of DCM diagnosis (that is, meeting clinical criteria for idiopathic
DCM)
- Any age (including children)
- Non-Hispanic and Hispanic ethnicity
- All races (PI pre-approval required for recruitment beyond pre-specified recruitment
targets).
- Ability to give informed consent
- Ability to communicate in English (except Spanish language at sites approved to
recruit individuals of Hispanic ethnicity)
- Willingness to participate in a family-based study (patient willing to work with a
clinical site and/or OSU to facilitate the recruitment and enrollment of family
members to the study).
Exclusion Criteria:
- Coronary artery disease (CAD) causing ischemic cardiomyopathy (> 50% narrowing, any
major epicardial coronary artery)
- Primary valvular disease
- Adriamycin or other cardiotoxic drug exposure
- Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right
Ventricular Dysplasia/Cardiomyopathy
- Congenital heart disease
- Other detectable causes of dilated cardiomyopathy, including sarcoid and
hemochromatosis.
- Other active multi-system disease that may cause DCM (e.g., active connective tissue
disease).
- Severe and untreated or untreatable hypertension (systolic blood pressures routinely
greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if
resistant to multidrug treatment).
- However, conventional risk factors for DCM, including obesity, routinely treated
hypertension, alcohol use, pregnancy or the peri-partum period, or left ventricular
noncompaction, will NOT be considered exclusion criteria.
Intervention(s):
behavioral: Family Heart Talk Booklet
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
DCM Coordinators
650 725-6911