Trial Search Results

Intermittent Theta-Burst Stimulation to Target Irritability in Adults With ASD

This study aims to demonstrate the feasibility, tolerability, safety and preliminary efficacy of 6 weeks of fMRI-guided iTBS delivered to personalized regions of the prefrontal cortex (PFC) in adults with ASD in reducing irritability in adults with ASD.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Device: Intermittent theta-burst stimulation (iTBS)

Phase:

N/A

Eligibility


Inclusion Criteria:

   1. Diagnosis of ASD or Asperger's based on DSM-5 criteria as confirmed by a qualified
   clinician (including Dr. Fung), and if necessary the administration of Autism
   Diagnostic Interview-Revised (ADI-R) and/or Autism Diagnostic Observation
   Schedule-Generic (ADOS-G)

   2. Age 22 to 55.

   3. Adults who are physically healthy.

   4. No significant current psychosocial stressors per history.

   5. Full scale IQ > 50.

   6. ABC-I score of 18 or greater.

   7. if the participant is taking medication, they must be stable on this medication
   regiment for at least 4 weeks prior to baseline and agree to stay on these medications
   for the duration of the trial

Exclusion Criteria:

(f) Pre-term birth (<34 weeks' gestation) (g) Low birth weight (<2000 g). (h) DSM-5
diagnosis of other severe psychiatric disorder such as bipolar disorder or schizophrenia.

(i) Current use of benzodiazepines. (j) Use of other medications that modulate the GABA(A)
receptor within 4 weeks of scanning (8 weeks for fluoxetine).

(k) History of alcoholism or substance abuse. (l) Active medical problems such as unstable
seizures, congenital heart disease, endocrine disorders.

(m) Significant sensory impairments such as blindness or deafness. (n) Contraindication for
MRI. (o) Pregnancy. (p) evidence of genetic syndrome.

Ages Eligible for Study

22 Years - 55 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Eleanor Cole, PhD
4157247960
Not Recruiting