Trial Search Results

Side Effects of Antipsychotic Medications

Medications like olanzapine have been associated with the development of weight gain and diabetes in some patients. It is not known if the increased risk of developing diabetes is a direct effect on insulin or simply related to weight gain.

We hope to learn in this study whether or not olanzapine directly slows down insulin secretion from the pancreas, thereby increasing the risk of developing diabetes.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):


Inclusion Criteria:

   - Participants 30-66 years of age

   - Body mass index (BMI) >25 < 35 kg/m2.

   - Fasting plasma glucose concentration < 126 mg/dL

   - Stable on one of the following psychiatric medication: Olanzapine (Zyprexa®),
   Ziprasidone (Geodon®), Aripiprazole (Abilify®), or Risperidone (Risperdal®)

   - Stable on psychiatric medication for at least 3 months

Exclusion Criteria:

   - Medications that directly affect insulin-mediated glucose disposal

   - Intense suicidal impulses/intent

   - Alcohol or substance abuse for 3 months.

   - Major medical problems, i.e., clinically unstable medical disorder or condition;
   cardiovascular, hepatic, renal, gastrointestinal, pulmonary, endocrine or other
   systemic disease that would, in the investigator's clinical judgment interfere with
   the endocrine measures obtained in this study.

Ages Eligible for Study

30 Years - 66 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Lilla Nikolics, Ms
650-493-5000 Ext. 67289