Trial Search Results

Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients

The purpose of this chart review study is to determine whether the use of dexmedetomidine, a selective α2-adrenergic receptor agonist with sedative, analgesic, and antinociceptive properties, would be associated with a lower incidence of delirium when compared to propofol and midazolam. We hypothesize that sedation with dexmedetomidine following cardiac surgery with CPB will be associated with a lower incidence of postoperative delirium.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Abbott

Stanford Investigator(s):


  • Drug: Dexmedetomidine
  • Drug: Propofol
  • Drug: Midazolam


Inclusion Criteria:

   1. Diagnosis of a coronary artery disease, cardiac valve disease, or vascular problems
   requiring elective surgical intervention

   2. Age older than 18 years of age, less than 90 years of age

   3. Fluency in English, and willingness to participate in the study

   4. No history of recent (< 3 months) of alcohol or drug abuse

   5. No pre-operative evidence of heart block

   6. No history of dementia, schizophrenia, or post-traumatic stress disorder

Exclusion Criteria:

   1. A preexisting diagnoses of dementia, schizophrenia, active or recent alcohol or drug
   abuse/dependence; post-traumatic stress disorder; acute intoxication (i.e., positive
   urine drug and/or alcohol test at the time of initial evaluation or upon
   hospitalization for surgery)

   2. Age younger than 18, or older than 89 years of age

   3. Inability to understand enough English to complete required diagnostic testing

   4. Unwillingness to participate in the study

   5. Inability of subject or surrogate to consent.

   6. Pregnancy

Ages Eligible for Study

18 Years - 89 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305