Trial Search Results

Exercise Study Including Patients With Hypertrophic Cardiomyopathy

The long term health and cardiovascular benefits of a regular exercise program have been well-established. National guidelines recommend involvement in moderate aerobic fitness (i.e. walking, bicycling, light jogging, swimming) for patients with hypertrophic cardiomyopathy (HCM). However, data on potential benefits of recreational exercise, useful parameters for risk stratification, and methods of devising individual exercise prescriptions are completely lacking. The specific aims of this study are: 1) to devise a safe moderate intensity exercise training program in patients with HCM, and 2) to determine whether exercise training improves ability to perform activities and tasks, heart size and function, and quality of life in patients with HCM.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: University of Michigan

Stanford Investigator(s):


  • Behavioral: stop exercising


Inclusion Criteria:

   1. Ages 18 - 80 years old.

   2. Diagnosis of hypertrophic cardiomyopathy, defined by the presence of unexplained
   left-ventricular hypertrophy (wall thickening) > 13 mm in any wall segment.

   3. Exercise £ 30 minutes, 1 day per week for the previous 3 months.

   4. Agreement to be a participant in the study protocol and willing/able to return for

Exclusion Criteria:

   1. History of exercise-induced syncope or arrhythmias (ventricular tachycardia or
   non-sustained ventricular tachycardia).

   2. Medically refractory LV outflow tract obstruction being evaluated for septal reduction

   3. Less than 3 months post septal reduction therapy (surgery or catheter based

   4. Hypotensive response to exercise (> 20 mmHg drop in systolic blood pressure from peak
   blood pressure to post exercise blood pressure).

   5. Pregnancy.

   6. ICD placement in last 3 months or scheduled.

   7. Life expectancy less than 12 months.

   8. Inability to exercise due to orthopedic or other non-cardiovascular limitations.

Ages Eligible for Study

18 Years - 80 Years

Genders Eligible for Study


Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Lisa Garrett