Patient Functioning and Well-being, Economic, and Clinical Impact of Hemophilia A and Its Treatment

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Trial ID: NCT02396862

Purpose

The purpose of the study is to improve the understanding of key patient reported outcomes such as quality of life as well as clinical outcomes in hemophilia A, in a global real world setting.

Official Title

A Prospective, International, Longitudinal, Observational Disease Registry of Patient-reported Outcomes (PROs) and the Association With Hemophilia A and Its Treatment in Patients With Moderate to Severe Hemophilia A

Stanford Investigator(s)

Eligibility


Inclusion Criteria:

   - Age 16 or over.

   - Have documentation of physician-confirmed diagnosis of moderate or severe Hemophilia A
   (severity defined as moderate = FVIII activity 1% to 5% and severe = FVIII activity
   ≤1%).

   - Signed written informed consent provided by the patient or the patient's parents for
   patients under the age of 18 (dependent of local regulations).

   - Signed written assent is also required for patients under the age 18 years (dependent
   on local regulations).

   - Plan to receive at least half of their Hemophilia care at the registry site.

   - Willing and able to enter data as per the data collection schedule.

   - Currently receiving prophylactic or on demand treatment (including within last 6months
   for on demand).

   - Expected life expectancy of at least 2 years.

Exclusion Criteria:

   - Patients with Hemophilia B

   - Patients with von Willebrand disease (vWD)

   - Patients with other rare bleeding disorders

   - Unable to comply with the study protocol

Intervention(s):

drug: Available Recombinant, and Human Factor VIII products incl. Kogenate FS (Recombinant Factor VIII, BAY14-2222)

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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305