Trial Search Results

PIEB vs CEI for Labor Analgesia: An MLAC Study

Utilizing a 'minimal local analgesic concentration (MLAC) study' design to first determine the relative potency of Programmed Intermittent Epidural Bolus (PIEB) compared to Continuous Epidural Infusion (CEI) and secondly to determine the mechanism to explain the potential PIEB efficacy advantage.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Manchester University NHS Foundation Trust

Stanford Investigator(s):


  • Drug: Bupivacaine
  • Drug: Sufentanil


Phase 4


Inclusion Criteria:

   - ASA I & II, Nulliparous and Multiparous, Spontaneous/Induced/Augmented Labor, Early
   active labor (cervix <5 cm (if known)), Pain (VPS) > 3, 18-45 years of age

Exclusion Criteria:

   - <37 weeks gestation, H/o Cesarean Section, Multiple Gestation, Pre-eclampsia,
   Narcotics within 3 hours prior to labor epidural placement, Chronic Pain (as defined
   by chronic opiate consumption), Women who are participating in another study that will
   impact protocol

Ages Eligible for Study

18 Years - 45 Years

Genders Eligible for Study


Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Aramina Aksamit, RN