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A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
Not Recruiting
Trial ID: NCT03144232
Purpose
This investigation will preliminarily determine if a course of high-frequency rTMS applied to
the left dorsolateral prefrontal cortex, will reduce behavioral craving, and fMRI
cue-reactivity in treatment-seeking cannabis use disordered participants.
Official Title
A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
Stanford Investigator(s)
Gregory Lee Sahlem
Assistant Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology)
Eligibility
Inclusion Criteria:
1. Participants must be able to provide informed consent and function at an intellectual
level sufficient to allow accurate completion of all assessment instruments.
2. Participants must be between the ages of 18 and 60.
3. Participants must meet DSM-5 criteria for at least moderate Cannabis Use Disorder,
with use of at least 20 out of the last 28 days.
4. Participants must express a desire to quit cannabis.
5. Participants must have a Positive UDS for cannabis during their baseline visit
(confirming they are regular users).
Exclusion Criteria:
1. Participants must not be pregnant or breastfeeding.
2. Participants must not meet moderate or severe use disorder of any other substance with
the exception of Nicotine Use Disorder.
3. Participants must not be on any medications that have central nervous system effects.
4. Participants must not have a history of/or current psychotic disorder or bipolar
disorder.
5. Participants must not have any other Axis I condition requiring current treatment and
must have a HRSD24 ≤10 indicating no clinically relevant depressive symptoms.
6. Participants must not have a history of Dementia or other cognitive impairment.
7. Participants must not have active suicidal ideation, or a suicide attempt within the
past 90 days.
8. Participants must not have any contraindications to receiving rTMS (e.g. metal
implanted above the head, history of seizure, any known brain lesion).
9. Participants must not have any unstable general medical conditions.
Intervention(s):
device: Active rTMS
device: Sham rTMS
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Study Team
650-374-0907