Trial Search Results
Diagnostic Performance of Coronary CT Angiography With CT FFR in Kidney Transplantation Candidates
Patients with chronic kidney disease (CKD) before kidney transplantation require that obstructive coronary artery disease (CAD) is excluded, as cardiovascular complications are the leading cause of mortality in kidney transplant patients. However, in this patient population, the optimal method for the detection of obstructive CAD has not been identified. Noninvasive stress tests such as Dobutamine stress echocardiography or nuclear perfusion study have low diagnostic accuracy. CT fractional flow reserve measurement (CT FFR) is a novel non-invasive (FDA approved) imaging test to identify obstructive CAD. The goal of this project is to evaluate the diagnostic accuracy of CT FFR in the detection of obstructive coronary artery disease in patients with chronic kidney disease before kidney transplantation.
Stanford is currently not accepting patients for this trial.
Collaborator: Siemens Medical Solutions
- Diagnostic Test: CT FFR
- Candidates for kidney transplantation on dialysis without any residual kidney function
AND referred to invasive coronary angiography for cardiac evaluation
- Referral to invasive coronary angiography is based on algorithm used at the Transplant
Readiness Assessment Clinic (TRAC) at Stanford:
- A. Diabetic Candidates older than 45 years.
- B. Diabetic Candidates under 45 years old and any one of the following criteria is
- a) 25 year History of Diabetes
- b) 5 year Smoking History
- c) Abnormal EKG (ST-T wave changes)
- Hemodynamically and clinically unstable condition (angina at rest, malignant
- Known ischemic heart disease (prior, documented myocardial infarction, prior stenting
or coronary artery bypass graft surgery)
- BMI>30 kg/m2, or weight >120 kg.
- Atrial fibrillation or other arrhythmia, >6 ectopic beats per minute
- Known or suspected allergy to iodinated contrast medium
- Pregnancy cannot be excluded
Ages Eligible for Study
21 Years - N/A
Genders Eligible for Study