Trial Search Results

Short Course Vaginal Cuff Brachytherapy in Treating Patients With Stage I-II Endometrial Cancer

This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating patients with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

University of Utah

Stanford Investigator(s):

Intervention(s):

  • Radiation: Vaginal Cuff Brachytherapy
  • Radiation: Short course vaginal cuff brachytherapy

Phase:

Phase 3

Eligibility


Inclusion Criteria:

   - Histologically confirmed endometrial carcinoma: endometrioid type, serous, and clear
   cell, to include tumors originating in the cervix, but are primarily located in the
   uterus, and for whom vaginal cuff brachytherapy is indicated. Carcinosarcoma and other
   sarcomas are permitted; Federation of Gynecology and Obstetrics (FIGO) stage I, with
   one of the following combinations of stage and grade:

      - Stage IA, grade 2, 3

      - Stage IB, grades 1-3

      - Stage II, grades 1-3

   - Patients post hysterectomy and free from residual disease

   - World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG)-performance
   status 0-2

   - Able to provide informed consent and willing to sign an approved consent form that
   conforms to federal and institutional guidelines

   - Life expectancy of >2 years.

Exclusion Criteria:

   - Stages of endometrial carcinoma other than described

   - Previous pelvic radiotherapy

   - Interval between the hysterectomy and planned start of radiotherapy exceeding 16 weeks

Ages Eligible for Study

N/A - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Akschy Peer
650-736-0792
Not Recruiting